The novel, high-affinity, monoclonal antibody lebrikizumab demonstrated significant efficacy in a dose-dependent manner across a range of clinical manifestations of moderate-to-severe atopic dermatitis (AD), including pruritus and quality of life (QoL), a phase IIb study has shown.
Current algorithm-based smartphone apps show poor and variable performance in detecting all cases of melanoma or other skin cancer, a systematic review of diagnostic accuracy studies has found. Moreover, the existing assessment processes for awarding the Conformit Europenne (CE) marking for these apps are inadequate for protecting the public.
There is a high prevalence of metabolic syndrome (MetS) in patients with psoriasis in Singapore, which is nearly threefold higher than the general population, results of a cross-sectional study have shown.
Repetitive, daily, high-frequency emollient therapy enhanced skin barrier integrity and function of premature and full-term neonates in communities with high relative humidity and temperature conditions, with sunflower seed oil (SSO) exhibiting a potential protective effect, according to a Nepalese study.
Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).