Excision with narrow margins does not predict mortality or recurrence in patients with Merkel cell carcinoma, results of a study have shown. Residual tumour, found primarily on deep surgical margins, is independently associated with prognosis.
The oral Janus kinase (JAK) inhibitor abrocitinib, otherwise called jakinib, does well in patients 12–17 years of age with atopic dermatitis (AD) in the phase III JADE TEEN study, providing instant itch relief.
Several comorbidities associated with psoriasis vulgaris are also prevalent in patients with plaque palmoplantar psoriasis (PPP), a recent study has found. In addition, individuals with PPP have a particularly high risk for mood disorders.
High cumulative exposure to hydrochlorothiazide (HCTZ) may result in the development of keratinocyte carcinoma and invasive squamous cell carcinoma (SCC), a study has shown, noting that sun protective behaviours alone may not be enough to eliminate the carcinogenic potential of HCTZ.
Treatment with topical corticosteroid monotherapy in early-stage mycosis fungoides (MF) can lead to measurable improvements in body surface area (BSA) and modified Severity-Weighted Assessment Tool (mSWAT) scores and even achievement of complete remission in some patients, a study has found.
Several lifestyle and environmental factors, including obesity and being overweight, predict the onset of psoriatic arthritis (PsA) among patients with psoriasis, indicating that such risk may be modified through lifestyle changes or avoidance of physical trauma, according to a study.
Survival is worse among patients with advanced BRAFV600 wild-type melanoma than those with BRAFV600-mutant advanced melanoma during the first 10 months following diagnosis due to limited treatment options, according to a Dutch study.
Treatment with corticosteroids in combination with intravenous immunoglobulin (IVIg) is associated with a reduction in mortality risk among patients with Stevens-Johnson syndrome (SLS) and toxic epidermal necrolysis (TEN) overlap and TEN, a recent study has shown.
While early-phase clinical trials may demonstrate substantial levels of overall response rates in patients with relapsed/refractory multiple myeloma (RRMM), high heterogeneity of evidence prevents the accurate assessment of clinical benefit before patient participation, reports a recent meta-analysis.
The COVID-19 vaccine AZD1222 by AstraZeneca and the University of Oxford was 79 percent effective overall in preventing symptomatic infections – higher than observed in previous clinical trials of the vaccine – at the interim analysis of a US phase III trial.
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.