More advanced stages of cutaneous melanoma are usually diagnosed among unmarried patients, especially men and those younger than 68 years of age, even in visible sites such as the face, according to a US study. In addition, these patients have worse survival independent of stage.
A phase I, single-centre, open-label study has found that repeated intravenous infusions of KHK4083, an investigational human monoclonal antibody, is sufficiently safe and clinically effective for the treatment of moderate to severe atopic dermatitis (AD).
Use of dipeptidyl-peptidase 4 (DPP-4) inhibitors is linked to the development of bullous pemphigoid, although the risk increase appears to be limited to linagliptin, according to the results of a meta-analysis.
Patients with cancer who are receiving vascular endothelial growth factor receptor–tyrosine kinase inhibitors (VEGFR-TKIs) are at increased risk of developing hand-foot skin reaction (HFSR), results of a recent meta-analysis have shown.
Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.