Major depressive disorder (MDD) patients who do not respond at the second week of treatment with mirtazapine monotherapy, paroxetine monotherapy or their combination appear to show improvements at the eighth week of treatment, according to a study. The data do not support recommendations to routinely offer additional treatment or a switch in treatment strategy to patients who exhibit nonresponse early in the treatment.
Mental disorders and chronic physical conditions represent a serious public health burden in Singapore, with chronic pain, major depressive disorder, obsessive compulsive disorder, cardiovascular disease and generalized anxiety disorder being the top five contributors to increased number of years lived with disability in the general population, according to a recent study.
A school-based combined online intervention focusing on prevention of substance use, depression, and anxiety reduced alcohol consumption and anxiety symptoms in adolescents, a study from Australia showed.
Among older patients with chronic low back pain and depression who are treated with venlafaxine, exposure to opioids is associated with reduced likelihood of achieving early pain response but not that of attaining the combined pain/depression outcome, a study has shown.
Routine prescription of a hypnotic medication does not appear to substantially reduce suicidal ideation in depressed outpatients with insomnia, but coprescription of such drug during antidepressant initiation may help suicidal outpatients, particularly those with severe insomnia, suggest the results of a study.