cushing's%20syndrome
CUSHING'S SYNDROME
Cushing’s syndrome is a condition which is due to prolonged exposure of the body tissue to excess cortisol (glucocorticoid hormone).
Laboratory tests and radiological findings confirm diagnosis and determine the actual cause of Cushing's syndrome.
Endogenous adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome has adrenal hypersecretion due to adrenal adenoma, adrenal carcinoma, micronodular hyperplasia, and macronodular hyperplasia.
Exogenous ACTH-independent Cushing's syndrome has adrenal hypersecretion due to iatrogenic causes (eg drug-induced, corticosteroid use).

Cushing's Syndrome References

  1. Arnaldi G, Angeli A, Atkinson AB, et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab. 2003 Dec;88(12):5593-5602. PMID: 14671138
  2. Boscaro M, Barzon L, Fallo F, et al. Cushing's syndrome. Lancet. 2001 Mar;357(9258):783-791. PMID: 11253984
  3. Newell-Prince J, Grossman A. Diagnosis and management of Cushing's syndrome. Lancet. 1999 Jun;353(9170):2087-2088. PMID: 10382687
  4. Findling JW, Raff H. Screening and diagnosis of Cushing's syndrome. Endocrinol Metab Clin North Am. 2005 Jun;34(2):385-402. PMID: 15850849
  5. Kirk LF, Hash RB, Katner HP, et al. Cushing's disease: clinical manifestations and diagnostic evaluation. Am Fam Physician. 2000 Sep;62(5):1119-1134. PMID: 10997535
  6. Findling JW, Raff H. Cushing's Syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab. 2009 Oct;91(10):3746-3753. PMID: 16868050
  7. Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008 May;93(5):1526-1540. PMID: 18334580
  8. Nieman LK, Ilias I. Evaluation and treatment of Cushing's syndrome. Am J Med. 2005 Dec;118(12):1340-1346. PMID: 16378774
  9. Orth DN. Cushing's syndrome. N Engl J Med. 1995 Mar;332(12):791-803. PMID: 7862184
  10. Pivonello R, De Martino M, De Leo M, et al. Cushing's Syndrome. Endocrinol Metab Clin North Am. 2008 Mar;37(1):135-149. PMID: 18226734
  11. Thorner MO, Besser GM. Cushing's Syndrome. Comprehensive clinical endocrinology. 3rd ed. London: Mosby; 2002
  12. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  13. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  14. Adler GK. Cushing Syndrome. http://emedicine.medscape.com/article/117365-overview. Jan 2008.
  15. National Endocrine and Metabolic Diseases Information Service (NEMDIS). Information on endocrine and metabolic diseases: Cushing's syndrome. http://www.endocrine.niddk.nih.gov/pubs/cushings/cushings.aspx. Jul 2008
  16. Nieman LK, Biller BM, Findling JW, et al. Treatment of cushing’s syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015 Aug;100(8):2807-2831. doi: 10.1210/jc.2015-1818. PMID: 26222757
  17. Almeida MQ, Lodish M, Stratakis, CA. Cushing's syndrome. In: Kellerman RD, Bope ET, eds. Conn's Current Therapy 2018. Philadelphia: Saunders, an imprint of Elsevier Inc; 2018. 261-266. :261-266.
  18. Nelson P, Gossain VV. AACE module on Cushing’s syndrome. American Association of Clinical Endocrinologists . www.aace.com.
  19. Nieman LK. Epidemiology and clinical manifestations of Cushing’s syndrome. UpToDate. www.uptodate.com. Jan 2017.
  20. Nieman LK. Establishing diagnosis of Cushing’s syndrome. UpToDate. www.uptodate.com. Sep 2017.
  21. Valassi E, Franz H, Brue T, et al. Diagnostic tests for Cushing’s syndrome differ from published guidelines: data from European Registry on Cushing’s Syndrome (ERCUSYN). Eur J Endocrinol. 2017 May;176(5):613-624. doi: 10.1530/EJE-16-0967. PMID: 28377460
  22. Adrenal Insufficiency Coalition; Adrenal Insufficiency United. Glucocorticoid tapering and adrenal suppression testing guide. https://aiunited.org. Sep 2016.
  23. Furst DE, Saag KG. Glucocorticoid withdrawal. UpToDate. https://www.uptodate.com. Jul 2017. Accessed 15 Jul 2019.
  24. Hopkins RL, Leinung MC. Exogenous Cushing’s syndrome and glucocorticoid withdrawal. Endocrinol Metab Clin North Am. 2005 Jun;34(2):371-384. doi: 10.1016/j.ecl.2005.01.013. PMID: 15850848
  25. Lacroix A. Dexamethasone suppression tests. UpToDate. https://www.uptodate.com. Sep 2017.
  26. Liu D, Ahmet A, Ward L, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013 Aug;9(1):30. doi: 10.1186/1710-1492-9-30. Accessed 11 Jul 2019. PMID: 23947590
  27. Lonser RR, Nieman L, Oldfield EH. Cushing’s disease: pathobiology, diagnosis and management. J Neurosurg. 2017 Feb;126(2):404-417. doi: 10.3171/2016.1.JNS152119. PMID: 27104844
  28. Nieman LK. Establishing the cause of Cushing’s syndrome. UpToDate. https://www.uptodate.com. Sep 2017.
  29. Nieman L. Recent updates on the diagnosis and management of Cushing’s syndrome. Endocrinol Metab. 2018 Jun;33(2):139-146. doi: 10.3803/EnM.2018.33.2.139. PMID: 29947171
  30. Stewart PM, Newell-Price JDC. The adrenal cortex. In: Melmed S, Polonsky KS, Larsen P, et al. Williams Textbook of Endocrinology. 13th ed. Philadelphia, Pennsylvania, USA: Saunders, Elsevier; 2016. 489-555. :489-555.
  31. Wagner-Bartak NA, Baiomy A, Habra MA, et al. Cushing syndrome: diagnostic workup and imaging features, with clinical and pathologic correlation. AJR Am J Roentgenol. 2017 Jul;209(1):10-32. doi: 10.2214/AJR.16.17290. PMID: 28639924
  32. Zoorob RJ, Cender D. A different look at corticosteroids. Am Fam Physician. 1998 Aug;58(2):443-450. PMID: 9713398
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