Cushing’s syndrome is a condition which is due to prolonged exposure of the body tissue to excess cortisol (glucocorticoid hormone).
Laboratory tests and radiological findings confirm diagnosis and determine the actual cause of Cushing's syndrome.
Endogenous adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome has adrenal hypersecretion due to adrenal adenoma, adrenal carcinoma, micronodular hyperplasia, and macronodular hyperplasia.
Exogenous ACTH-independent Cushing's syndrome has adrenal hypersecretion due to iatrogenic causes (eg drug-induced, corticosteroid use).

Differential Diagnosis

  • Identify cause & treat appropriately
  • Pseudo-Cushing’s syndrome
    • Due to non-endocrine disorders (eg major depressive disorder or chronic alcoholism)
    • Identify the cause & treat appropriately
    • Major causes: Major depressive disorder, chronic alcoholism
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