Constipation is an unsatisfactory defecation distinguished by difficult stool passage, infrequent stools or both.
Difficult stool passage may include straining, feeling of difficulty in passing stool, incomplete evacuation, lumpy/hard stools, prolonged time to defecate, need for manual maneuver to pass stool, abdominal discomfort and feeling of anorectal blockade.
Chronic constipation is considered when symptoms of constipation have existed ≥3 months.
Symptoms of chronic constipation may be due to dysfunction of intestinal motility, visceral sensitivity, anorectal musculature or the enteric nervous system.
The novel local-acting ileal bile acid transporter inhibitor elobixibat helps relieve chronic constipation in the short term, with well tolerated safety profile in the long term — supporting the novel approach of increasing intracolonic bile acid concentration for treating chronic constipation, two phase III studies show.
Depression appears to be a stronger predictor of absenteeism than symptom severity in patients with chronic constipation, suggests a study, adding that depression may partly contribute to the indirect costs of chronic constipation.
Use of plecanatide in the treatment of chronic idiopathic constipation appears to induce notable improvements in bowel movement frequency, stool consistency, and straining and abdominal symptoms, with a low incidence of adverse events, according to the results of a phase III trial.
Absenteeism among patients with chronic constipation appear to have a stronger association with depression than symptom severity, according to a recent study, suggesting that a portion of the indirect costs of chronic constipation is attributable to depression.
Prucalopride elicits more high amplitude propagating contractions compared with PEG3350 in the 12-hour period following treatment among patients with chronic constipation, a randomised, cross-over, reader-blinded study has shown.
Rebamipide reduces atypical gastrointestinal (GI) symptoms, including gastroesophageal reflux, gastroparesis, peptic ulcer, and constipation, in patients with type 2 diabetes mellitus (T2DM), according to an investigator-initiated clinical trial.
Noninclusion of antibiotics in the management of uncomplicated acute diverticulitis is feasible and fairly safe, with long-term follow-up data from the DIABOLO study showing that such a strategy does not result in increased incidence of complicated or recurrent diverticulitis or sigmoid resections over 2 years.
Consumption of whole-cricket powder appears to promote the growth of the probiotic gut bacterium Bifidobacterium animalis and reduce plasma concentrations of tumour necrosis factor-α, according to a recent trial.