Colorectal cancer is a carcinoma arising from the luminal surface of the colon.
It is the 2nd most common cancer in women and third most common cancer in male worldwide. It commonly arises from adenomatous polyps.
It is strongly linked to age with 83% occurring in people ≥60 years old.
Rectal cancer is defined as cancerous lesions located within 12 cm of the anal verge.
A rare copy number variant region (CNVR) at chromosome 14q11, encompassing the CHD8 gene for chromatin modification, is associated with sporadic colorectal cancer (CRC) risk such that the loss of copy number affects the expression of genes involved in CRC tumourigenesis, a recent Singapore study has shown.
Sodium phosphate (NaP) tablets for bowel preparation prior to colonoscopy are safe, better tolerated by patients, and provide equivalent and possibly superior colon cleansing compared with standard polyethylene glycol (PEG) solution, a Korean study has found.
Intraoperative laparoscopy and laparoscopic ultrasonography (LUS) offer no clear advantage over preoperative imaging techniques, such as computed tomography and magnetic resonance imaging, in terms of tumour, node and metastasis (TNM) staging and treatment strategy in colorectal cancer, according to a new study.
New drug applications approved by US FDA as of 1 - 15 September 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Liquid biopsy at disease progression effectively identifies novel and heterogeneous mechanisms of acquired resistance to targeted therapies in patients with a range of gastrointestinal (GI) cancers, which may help guide subsequent therapy.
The Asian Pacific Digestive Week (APDW) 2017, to be held in Hong Kong on 23–26 September, will examine key issues in and the future of digestive disease management in the Asia-Pacific region. Professor Justin Wu of the Chinese University of Hong Kong (CUHK), Congress President of APDW 2017 and President of the Hong Kong Society of Gastroenterology, talks to MIMS Doctor about challenges the region is facing and shares highlights of the upcoming congress.
Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin after colorectal cancer (CRC) diagnosis was associated with improved survival, in particular among patients with KRAS wild-type tumours.
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.