Treatment Guideline Chart
Clostridioides (formerly Clostridium) difficile infection is commonly associated with antibiotic treatment and is one of the most common nosocomial infections.
Symptoms usually start on days 2-3 of antibiotic treatment, but may also occur up to 8-12 weeks after discontinuation of antibiotics.
Discontinuation of antibiotics may be the only measure needed for patients with only mild diarrhea, no fever, no abdominal pain nor a high WBC count.
Cessation of antibiotics allows for reconstitution of the normal colonic microflora and markedly reduces risk of recurrence.

Clostridioides%20difficile%20infection Management

Infection Control Measures

  • Isolate patients with C difficile-associated diarrhea
  • Use precautions (eg gloves, gowns) when in contact with the infected patient and the environment
    • Maintain contact precautions until diarrhea has resolved 
  • Proper handwashing between patient contacts must be observed
  • Reusable devices and equipment must be properly disinfected
  • Educate patient and hospital staff regarding the disease
  • Judicious use of antibiotics (ie proper antibiotic stewardship) must be exercised to prevent further cases of infection
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