Chronic myelogenous leukemia (CML) is a malignant myeloid disorder characterized by the presence of a distinctive cytogenetic abnormality known as the Philadelphia chromosome.

Exposure to ionizing radiation is the only known risk factor with median presentation at age >50 years old.

Three phases of the disorder are chronic, accelerated and blast.

Choice of therapy is influenced by age, availability of a donor, comorbidities and phase of CML.

Chronic Myeloid Leukemia References

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  23. Van Etten RA. Molecular genetics of chronic myeloid leukemia. UptoDate website. molecular-genetics-of-chronic-myeloid-leukemia? source=search_result&search=Quantitative+ RT-PCR+%28QPCR%29&selectedTitle=5~150. Sep 2015.
  24. Waclaw J, Sacha T, Soklosa T. Imatinib in the treatment of chronic myeloid leukemia: Current perspectives on optimal dose. Cancer Therapy Advisor. optimal-dosage/article/438571/. Sep 2015.
  25. World Health Organization. Chronic myelogenous leukemia. World Health Organization website. /applications/CML.pdf?ua=1. 2014.
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