chronic%20myeloid%20leukemia
CHRONIC MYELOID LEUKEMIA

Chronic myelogenous leukemia (CML) is a malignant myeloid disorder characterized by the presence of a distinctive cytogenetic abnormality known as the Philadelphia chromosome.

Exposure to ionizing radiation is the only known risk factor with median presentation at age >50 years old.

Three phases of the disorder are chronic, accelerated and blast.

Choice of therapy is influenced by age, availability of a donor, comorbidities and phase of CML.

Differential Diagnosis

  • Leukemoid reaction
  • Juvenile myelomonocytic leukemia
  • Chronic myelomonocytic leukemia
  • Atypical chronic myeloid leukemia
  • Chronic eosinophilic leukemia
  • Chronic neutrophilic leukemia
  • Other myeloproliferative neoplasms (eg essential thrombocytopenia, polycythemia vera)
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