chronic%20lymphocytic%20leukemia
CHRONIC LYMPHOCYTIC LEUKEMIA
Treatment Guideline Chart

Chronic lymphocytic leukemia (CLL) is a malignant, chronic lymphoproliferative disorder characterized by proliferation and accumulation of monoclonal B-cells in the bone marrow, peripheral blood, lymph nodes, liver and spleen.

It is the most common form of adult leukemia in the Western world but rare in Asians.

Exact etiology is unknown but usually associated with genetic aberrations and lesions.

 

Chronic%20lymphocytic%20leukemia Signs and Symptoms

Introduction

  • The most common form of adult leukemia in the Western world but less common in Asians

Definition

  • A chronic lymphoproliferative disorder characterized by progressive accumulation of monoclonal B-cell lymphocytes found in the blood and bone marrow

Pathophysiology

  • Commonly associated genetic aberrations include:
    • Good prognosis: Deletions of chromosome 13q
    • Poor prognosis: 17p, 11q chromosomal deletion, trisomy 12, TP53, NOTCH1, SF3B1, RPS15 gene mutations, ATM mutations with or without BIRC3 deletion, CD49d, CD38 expression, ZAP-70 expression

Signs and Symptoms

  • Enlarged lymph nodes
  • Systemic symptoms: Tiredness, fever, night sweats, weight loss
  • Symptoms of anemia or infection

Risk Factors

  • Chemical exposure
  • Family history - 1st-degree relatives (6- to 9-fold increased risk)
  • Race - higher incidence in Caucasians compared to African Americans and Asians
  • Gender - increased incidence in men compared to women
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