chronic%20lymphocytic%20leukemia
CHRONIC LYMPHOCYTIC LEUKEMIA

Chronic lymphocytic leukemia (CLL) is a malignant, chronic lymphoproliferative disorder characterized by proliferation and accumulation of monoclonal B-cells in the bone marrow, peripheral blood, lymph nodes, liver and spleen.

It is the most common form of adult leukemia in the Western world but rare in Asians.

Exact etiology is unknown but usually associated with genetic aberrations and lesions.

 

Introduction

  • The most common form of adult leukemia in the Western world but less common in Asians

Definition

  • A chronic lymphoproliferative disorder characterized by progressive accumulation of monoclonal B-cell lymphocytes found in the blood & bone marrow

Pathophysiology

  • Commonly associated genetic aberrations include:
    • p53 tumor suppressor gene mutation
    • Chromosomal deletions (eg chromosome 17p, chromosome 11q, chromosome 13q)
    • Chromosomal alteration (trisomy 12)

Signs and Symptoms

  • Enlarged lymph nodes
  • Systemic symptoms: tiredness, fever, night sweats, weight loss
  • Symptoms of anemia or infection

Risk Factors

  • Chemical exposure
  • Family history - 1st degree relatives
  • Race - higher incidence in Caucasians compared to African Americans & Asians
  • Gender - increased incidence in men compared to women
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