Chronic lymphocytic leukemia (CLL) is a malignant, chronic lymphoproliferative disorder characterized by proliferation and accumulation of monoclonal B-cells in the bone marrow, peripheral blood, lymph nodes, liver and spleen.

It is the most common form of adult leukemia in the Western world but rare in Asians.

Exact etiology is unknown but usually associated with genetic aberrations and lesions.


Differential Diagnosis

  • Hairy cell leukemia
  • Waldenstrom macroglobulinemia
  • Prolymphocytic leukemia
  • Follicular lymphoma
  • Mantle cell lymphoma
  • Monoclonal B-cell lymphocytosis (MBL)
  • Splenic marginal zone lymphoma
  • Infectious mononucleosis
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