A combination of the direct-acting antiviral agents (DAAs) ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) and dasabuvir (DSV) resulted in sustained virologic response at post-treatment week 12 (SVR12) in almost all Asian adult patients with genotype 1b (GT1b) chronic hepatitis C virus (HCV) infection without cirrhosis, according to the ONYX-I* study presented at the recent Asian Pacific Association for the Study of the Liver Annual Meeting (APASL 2017) held in Shanghai, China.
Treatment with the sphingosine1-phosphate 1 (S1P) and 5 (S1P5) receptor modulator ozanimod led to clinical, endoscopic, and histologic remission in patients with moderate-to-severe ulcerative colitis (UC), data from the ongoing TOUCHSTONE study have shown, offering hopes for novel oral therapeutics with distinct mechanisms of action.
Patients with early rheumatoid arthritis (RA) may benefit from the initial addition of certolizumab pegol (CZP) to optimized methotrexate (MTX) therapy, as this strategy potentially prevents joint destruction, according to the results of the phase III C-OPERA* study.
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) during acute respiratory infection episodes may increase the risk of acute myocardial infarction (MI), a recent study from Taiwan shows.
Treatment with ibandronate may effectively reduce bone mineral density (BMD) loss in women with rheumatoid arthritis (RA) who are receiving long-term glucocorticoids, according to a study.
Atrial fibrillation (AF) was associated with a higher rate of early adverse clinical outcomes after transcatheter aortic-valve replacement (TAVR), including all-cause mortality, compared with presentation in normal sinus rhythm. Additionally, fewer adverse outcomes occur post-TAVR in AF patients treated with apixaban than with a vitamin K antagonist (VKA), suggests a recent registry-based study.
A combination of nifedipine gastrointestinal therapeutic system (GITS) and candesartan cilexetil affords greater reductions in blood pressure (BP) in high-risk hypertensive patients compared with respective monotherapies and placebo, according to a posthoc analysis of the DISTINCT study. Furthermore, the vasodilatory side-effect profile is better with the combination than with nifedipine GITS monotherapy.
Antidepressant use during the first trimester of pregnancy may develop a higher risk of major congenital abnormalities, according to a recent study.
New drug applications approved by US FDA as of 1 - 15 February 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
A bihormonal bionic pancreas provides better glycaemic control and reduces hypoglycaemia without the painstaking need for carbohydrate counting compared with insulin pump therapy in patients with type 1 diabetes (T1D), a recent study has shown.