Patients w/ abnormal Pap smear are referred for colonoscopy to screen for presence of cervical cancer.
Colposcopic exam should include inspection of the transformation zone, definition of the extent of the lesion & biopsy of the most abnormal area for tissue diagnosis.
The earliest stages of cervical carcinoma are generally asymptomatic.
Watery vaginal discharge & postcoital bleeding or intermittent spotting may be present & are usually unrecognized by the patient.
Endocervical sampling with a new fabric-based curette device reduces the number of “inadequate” specimens and hence, the need for repeat biopsies compared with conventional metal scraping, reveals a recent study.
Patients with locally advanced cervical cancer should not be routinely treated with neoadjuvant chemotherapy (NACT) followed by surgery as this approach does not improve disease-free survival (DFS) or overall survival (OS) vs standard chemoradiotherapy (CRT), according to results of a phase III trial.
Dr Ravichandran Nadarajah, a consultant at the Department of Obstetrics & Gynaecology, Singapore General Hospital, speaks to Roshini Claire Anthony on the importance of early diagnosis and prevention of cervical cancer.
The addition of bevacizumab to chemotherapy improved overall survival (OS) in women with metastatic, persistent, or recurrent cervical cancer, according to the final OS analysis of the Gynecologic Oncology Group (GOG) 240 trial, confirming the findings observed in the interim analysis.
Five symptoms that affect bowel health may be attributed to late effects of radiotherapy, new study reports. Studying the underlying causes of these symptoms should simplify the prevention and treatment of a variety of other downstream symptoms.
Optimal screening of human papillomavirus (HPV) infection should identify the women who are most at risk for cervical cancer, according to a presentation at the recent Asia-Oceania Research Organisation in Genital Infection and Neoplasia (AOGIN) 2016 congress.
The American Society of Clinical Oncology (ASCO) has published its first clinical guideline on invasive cervical cancer, offering recommendations stratified by resource availability. [J Glob Oncol 2016, doi: 10.1200/JGO.2016.003954]
Aprepitant is effective in lessening nausea and vomiting in Japanese gynaecological cancer patients receiving paclitaxel and carboplatin combination chemotherapy, as reported in a multicentre, placebo-controlled, double-blind, randomised study.
A 2008 clinical practice guideline by the Endocrine Society for hirsutism in premenopausal women has been updated and published in the Journal of Clinical Endocrinology & Metabolism. [https://doi.org/10.1210/jc.2018-00241]