Roxadustat, an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, is noninferior to parenteral epoetin alfa and performs better than placebo for correcting anaemia in kidney disease patients who are or not undergoing dialysis, according to the results of two phase III trials from China.
Use of the proton pump inhibitor (PPI) pantoprazole does not cut the risk of upper gastrointestinal events but may reduce the risk of bleeding from gastroduodenal lesions in patients on low-dose anticoagulants and/or antiplatelet therapy, a study has shown.
Inhibition of phosphodiesterase-9 (PDE9-I) is associated with improved efficacy of natriuretic peptide (NP), as well as favourable haemodynamic and renal effects in experimental heart failure (HF), a recent study has shown.
The European Society of Cardiology (ESC) high-sensitivity cardiac troponin (hs-cTn) measurement at presentation and after 1 h (ESC hs-cTn 0/1 h algorithm) provides a better balance of efficacy and safety when predicting major adverse cardiac events (MACE), a study has shown. On the other hand, the extended algorithm is the preferred option for the rule-out of 30-day MACE with unstable angina (UA).
The coexistence of diabetes mellitus (DM) in Asian patients with heart failure (HF) who were receiving cardiac resynchronization therapy (CRT) attenuated CRT-induced left ventricular (LV) reverse modelling — a predictor of event-free survival — and was associated with worse clinical outcomes compared with patients without T2D, the PEACH* study shows.
Having identified the prevalence and increased risk of masked hypertension in pregnant women, a recent study suggests that an office blood pressure (BP) of at least 125/75 mm Hg in the second half of gestation may be appropriate to indicate out-of-office measurements in high-risk pregnancies.
An association seems to exist between an elevated blood pressure (BP) and a decrease in cognitive scores among functioning older adults, according to a recent study. Conversely, an elevated BP is associated with modest improvements in cognitive function among poorly functioning elders.
No association exists between a vegan diet and lower blood pressure (BP) measurements as compared with omnivorous alternatives, a study has found. The effect of a vegan diet in adults is similar to that by portion-controlled diets and those recommended by medical societies.
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
Treatment with low-to-standard dose dual combination therapy of blood pressure (BP)-lowering drugs is more effective than standard-dose monotherapy and does not increase withdrawals due to adverse events, a recent study has shown.
Untreated white coat hypertension (WCH), but not treated white coat effect (WCE), may increase the risk for cardiovascular events and all-cause mortality, suggest the results of a systematic review and meta-analysis. Out-of-office blood pressure (BP) monitoring is thus important in the diagnosis and management of hypertension.
Risk factors for 1-year mortality in heart failure (HF) patients significantly differ between those with and without chronic kidney disease (CKD), especially with regard to the use of beta-blockers or diuretics at discharge, according to a study. This suggests that these patients may benefit from individualized therapies.