Children with familial hypercholesterolemia (FH) who receive statin therapy in childhood could potentially delay the progression of carotid intima-media thickness and reduce their risk of cardiovascular (CV) disease (CVD) in adulthood, according to a long-term follow-up study.
The use of a genotype-guided strategy for selection of oral P2Y12 inhibitor therapy appears to benefit patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), such that noncarriers of CYP2C19 loss-of-function alleles have favourable bleeding outcomes with clopidogrel vs standard treatment with ticagrelor or prasugrel, according to data from the POPular Genetics* trial.
The addition of ticagrelor or clopidogrel to aspirin is effective in preventing saphenous vein graft failure following coronary artery bypass graft (CABG) surgery, results of a systematic review and meta-analysis have shown.
The use of ticagrelor in acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention appears to reduce the risk of major adverse cardiovascular and cerebrovascular events (MACCE) without increasing major bleeding episodes when compared with clopidogrel, although the former antiplatelet strategy may heighten the risk of minor bleeding, according to a study.
The 30-day mortality rates among patients undergoing transcatheter aortic valve replacement (TAVR) have decreased by more than half over the last decade, with significant differences between genders, a CENTER* collaboration analysis has shown.
In older adults with systolic hypertension, targeting a 24-hour ambulatory systolic blood pressure (BP) of ≤130 vs ≤145 mm Hg does not appear to be beneficial in terms of mobility outcomes during a 3-year period, although it yields a favourable effect on subcortical white matter disease, according to data from the INFINITY trial.
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
In patients with acute ST-segment elevation myocardial infarction (ASTEMI), the risk of new-onset atrial fibrillation (NOAF) appears to be linked with plasma levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), a recent China study has found.
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers.