Patients with atrial fibrillation (AF) enrolled in the prospective Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF) have been prescribed the recommended direct oral anticoagulant (DOAC) doses according to country-specific guidelines. However, use of nonrecommended doses persists and is associated with a higher risk of death, mostly of cardiovascular nature, reveals a study.
Shortness of breath, or dyspnoea after some exertion, can sometimes be associated with reduced fitness and ageing. However, GPs should not overlook the possibility that the symptom could be a warning sign of heart and lung diseases, experts caution.
Patients with COVID-19 who experience an ischaemic stroke may have worse outcomes, including greater stroke severity and mortality risk, than those without COVID-19, findings from the Global COVID-19 Stroke Registry showed.
The pupil of the eye may independently predict all‐cause mortality and readmission due to heart failure (HF), suggesting its prognostic predictive capability in patients with HF, a retrospective analysis has shown.
The use of aspirin alone following TAVI* significantly reduced bleeding vs aspirin plus clopidogrel in the POPular TAVI study. This benefit came without increasing thromboembolic events, effectively positioning aspirin as the better antithrombotic strategy after TAVI.
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Inhaled treprostinil significantly improves exercise capacity in terms of 6-minute walking distance (6MWD) over 16 weeks compared with placebo in patients with pulmonary hypertension associated with interstitial lung disease (ILD), according to the INCREASE trial presented at ATS 2020.
In patients with chronic heart failure with reduced ejection fraction (HFrEF), empagliflozin reduced the risk of cardiovascular (CV) death or heart failure hospitalization (HHF) and decline in estimated glomerular filtration rate (eGFR), results of the EMPEROR-Reduced* trial showed.
Adding dapagliflozin to standard of care (SOC) significantly reduces the risk of worsening kidney function, death due to kidney or cardiovascular (CV) disease, and all-cause mortality compared with SOC alone in patients with chronic kidney disease (CKD), regardless of whether they have type 2 diabetes (T2D), reveals the DAPA-CKD* trial — showing dapagliflozin charting new territories from diabetes to the renal realm.
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.