The addition of the glucagon-like peptide-1 analogue semaglutide to standard of care resulted in sustained reduction in weight and waist circumference in individuals with type 2 diabetes (T2D) with high cardiovascular risk, according to the phase III SUSTAIN 6* trial presented at EASD 2017.
The practice of giving oxygen to patients with MI is challenged by a recent registry-based randomized clinical trial showing that this widely accepted practice does not improve survival, according to results presented at the European Society of Cardiology Congress 2017 (ESC 2017) held in Barcelona, Spain.
In patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), dual antithrombotic therapy with dabigatran and a P2Y12 inhibitor significantly reduces bleeding vs triple therapy with warfarin, a P2Y12 inhibitor and aspirin, with comparable rates of thromboembolic events, results of the RE-DUAL PCI trial have shown.
Late-breaking results from a multinational trial show for the first time that adding anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, to intensive statin therapy reduces cardiovascular (CV) events in high-risk patients, with the possibility of providing greater benefit with longer duration of treatment.
Blocking the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) with one to two injections of small interfering RNA (siRNA) provides sustained LDL-cholesterol (LDL-C) lowering for up to 1 year in patients with high cardiovascular (CV) risk and elevated LDL-C levels, the phase II ORION-1 study has shown.
Late-breaking data presented at the European Society of Cardiology Congress 2017 in Barcelona, Spain have shown that ibuprofen is associated with greater increase in blood pressure (BP) than celecoxib or naproxen in patients with arthritis, potentially increasing their risk of cardiovascular (CV) events. [Eur Heart J 2017, doi: 10.1093/eurheartj/ehx508]
Very aggressive reduction of LDL-cholesterol with the proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitor evolocumab was associated with progressively fewer cardiovascular (CV) events without compromising safety in patients with established atherosclerotic disease, according to a secondary analysis of the FOURIER trial (Further Cadiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) presented recently at the European Society of Cardiology Congress 2017 in Barcelona, Spain. [Lancet 2017, doi: 10.1016/S0140-6736(17)32290-0]
Landmark results from the CASTLE-AF trial has demonstrated that catheter ablation significantly improves outcomes in patients with heart failure and atrial fibrillation (AF), reducing the risk of all-cause mortality and hospitalizations for worsening heart failure by more than one-third compared with conventional treatment.