Top Medical News
Higher echocardiographic calcium score seen in CVD patients on peritoneal dialysis
Stephen Padilla, 7 hours ago
Patients undergoing peritoneal dialysis (PD) with cardiovascular disease (CVD) show significantly higher echocardiographic calcium score (ECS) than those without CVD, according to a Singapore study. This indicates a higher vascular calcification burden in the former.
CIEDs give clues to time of patient death
Tristan Manalac, 10 hours ago
Postmortem interrogation of cardiac implantable electrical devices (CIED) can help pinpoint a patient’s time of death, according to a recent study. While forensic analysis of explanted CIEDs is valid, accuracy of time determination varies across different devices.
‘1-2-3-4-day rule’: Initiating DOACs according to stroke severity may be the way to go
Jairia Dela Cruz, Yesterday
Following nonvalvular atrial fibrillation (NVAF)-associated stroke events, a graded increase in delay in direct oral anticoagulants (DOACs) initiation of between 1 and 4 days, depending on the severity of the index event, appears to be effective for recurrent stroke prevention and does not compromise safety both in Asians and Europeans, according to a recent study.
Intensive BP management reduces CVD deaths in overweight, obese patients
Stephen Padilla, Yesterday
Intensive management of blood pressure (BP) leads to a significant reduction in cardiovascular events in overweight, obese I, and obese II patients without elevating safety risks, a study has shown.
High BNP predicts stroke or systemic embolism in very elderly NVAF patients
2 days ago
In very elderly nonvalvular atrial fibrillation (NVAF) patients who are ineligible for standard anticoagulation, increasing levels of B-type natriuretic peptide (BNP) appear to be correlated with higher risks of stroke or systemic embolism, reports a new study.
Canagliflozin improves HF symptoms, QoL regardless of diabetes status
2 days ago
A recent meta-analysis offers new proof of different canagliflozin doses for hypertension management in patients with type 2 diabetes mellitus (T2DM) complicated by hypertension. However, low-density lipoprotein cholesterol (LDL-C) and the risk of urinary tract infection must be observed.
In intermediate risk patients, the TAVR is found to have better outcomes
2 days ago
Implantation with new-generation, self-expanding aortic valves appears to result in a significant spike in the rates of high-degree cardiac conduction disturbance, such as an increase in PR and QRS intervals, reports a new study.
Special Reports
Early and consistent: Breakthrough results in HFpEF similar to HFrEF
14 Jan 2022
HFpEF represents a significant unmet need in CV medicine due to its prevalence, poor prognosis, and the absence of clinically proven therapeutic options. The EMPEROR-Preserved trial demonstrated the continuous clinical benefits in cardiorenal outcomes of empagliflozin in adults with HFpEF, which were consistent with the observations in adults with HFmrEF/ HFpEF in the EMPEROR-reduced trial. The combined results of the EMPEROR trials establish empagliflozin’s efficacy in heart failure regardless of ejection fraction – and if approved, empagliflozin would become the first and only clinically proven therapy to improve outcomes for the full spectrum of the disease. Therefore, empagliflozin offers a new hope for people living with heart failure.
EMPEROR-Preserved: The first successful trial to improve outcomes in HFpEF
18 Nov 2021
Heart failure with preserved ejection fraction (HFpEF) represents a significant unmet medical need. The EMPEROR-Preserved trial aimed to assess the impact of empagliflozin on cardiovascular outcomes in patients with HFpEF. On 27 August 2021, during the hotline session of the 2021 ESC Virtual Congress, the main results of the EMPEROR-Preserved trial were presented by Professor Stefan Anker, principal investigator of the study, and heart failure specialist at Charité Berlin, Germany.
NOACs in nonvalvular atrial fibrillation with multimorbidity: Where does apixaban stand?
02 Nov 2021
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice, affecting millions of people globally. Stroke is one of its devastating complications, with the risk steeply increasing with advancing age. Additionally, AF is associated with more than a tripling of the risk of systemic embolic (SE) events. [J Am Heart Assoc 2020;9:e016724]
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Trimetazidine new formulation redefining angina control in daily practice
12 Mar 2021
Chronic coronary syndrome (CCS) remains a leading cause of death and disability worldwide. The dual goals of CCS management is to prevent future cardiac events, such as myocardial infarction and death, and to reduce ischaemia and relieve angina symptoms, says Prof Peter Yan, consultant cardiologist and medical director, Peter Yan Cardiology Clinic, Gleneagles Medical Centre, Singapore, during a Servier-sponsored virtual symposium.
Empagliflozin not just another SGLT2i: Cardio-renal benefits extend to HF with or without diabetes
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Conference Reports
Post-TAVR SLT does not differ with edoxaban or DAPT
Roshini Claire Anthony, 16 May 2022

The risk of subclinical valve leaflet thrombosis (SLT) following transcatheter aortic valve replacement (TAVR) did not differ regardless of whether patients received edoxaban or dual antiplatelet therapy (DAPT) post-surgery, according to results of the ADAPT-TAVR* trial.

New HF guideline:
Quad therapy, HFmrEF, and more
Elvira Manzano, 04 May 2022
Hot on the heels of ACC.22 ground-breaking reports, the ACC/AHA/HFSA* released the 2022 heart failure (HF) guideline, with special emphasis on quad therapy for patients with reduced ejection fraction.
Aspirin for primary prevention
Stephen Padilla, 02 May 2022
Among patients on concomitant treatment with direct oral anticoagulants (DOACs) and dronedarone, no difference is seen in survival free from the composite endpoint (ie, clinically relevant bleeding, thromboembolic event, and all-cause death) and from clinically relevant bleeding between groups of coadministration, according to a study.
Exercise confers greater benefits in anxiety, depression
Elvira Manzano, 30 Apr 2022
The cardioprotective effects of exercise are nearly twice as large in people with anxiety and depression than in those without, suggests a new study presented at ACC.22.
Bipolar ablation of heart arrhythmia safe, effective in lieu of failed unipolar approach
Stephen Padilla, 29 Apr 2022
Use of bipolar radiofrequency ablation (BRFA) is both safe and effective in selected patients who have failed at least one standard unipolar approach, suggest the results of a systematic review and meta-analysis. However, the quality of the supporting evidence is low.
Sports-related sudden cardiac deaths: Why do men have it worse?
Audrey Abella, 28 Apr 2022
When it comes to sports-related* sudden cardiac death (SCD) rates, men appear to have it worse than women, according to data presented at EHRA 2022.
Adjunctive mavacamten averts need for invasive therapy in OHCM
Elvira Manzano, 28 Apr 2022
Adding mavacamten – an allosteric modulator of cardiac myosin – to maximal medical therapy slashes the need for septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy (OHCM) who are candidates for such intervention, the VALOR-HCM trial has shown.