Cardiology

Top Medical News
Aspirin prevents CVD in older adults with elevated lipoprotein(a) genotypes
5 hours ago
Use of aspirin offers health benefits to older individuals with elevated lipoprotein(a) genotypes by preventing cardiovascular events, suggests a study.
Dapagliflozin DELIVERs across full HF spectrum regardless of LVEF
Elvira Manzano, 16 hours ago
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
Hearts donated after circulatory vs brain death tied to post-transplant dysfunction
Yesterday
Utilization of hearts donated after circulatory death (DCD) appears to result in transient post-transplant right heart dysfunction and short-term clinical outcomes otherwise comparable to transplantation using hearts donated after brain death (DBD), reveals a recent study.
Reproductive factors implicated in atrial fibrillation risk in women
Yesterday
Reproductive factors such as irregular menstrual cycles, nulliparity, and multiparity contribute to an increased risk of new-onset atrial fibrillation in women, as reported in a study.
Use of RAS inhibitors associated with lower cancer risk in T2D
Natalia Reoutova, Yesterday

A real-world study of over 250,000 type 2 diabetes (T2D) patients from Hong Kong has found that use of renin-angiotensin-system inhibitors (RASIs) is independently associated with reduced risk of cancer, including diabetes-related cancers and cancer-specific mortality in diabetes.

beer compound for weight control
3 days ago
Recent evidence suggests that drinking alcoholic beverages is associated with cardiovascular diseases (CVD), including coronary artery disease (CAD), and all-cause mortality.
Calf vein thrombosis ups 30-day death risk in older adults with hip fractures
3 days ago
Among older adults suffering from hip fractures, calf deep vein thrombosis (DVT) appears to significantly aggravate the risk of 30-day all-cause mortality, a recent study has found. However, no such effect exists for the 90-day death risk.
Special Reports
Dapagliflozin DELIVERs across full HF spectrum regardless of LVEF
Elvira Manzano, 04 Oct 2022
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
Empagliflozin: A new dawn for heart failure treatment across the ejection fraction spectrum
06 Jun 2022

Initially approved to improve glycaemic control and reduce cardiovascular death in adults with type 2 diabetes (T2D), the SGLT-2* inhibitor empagliflozin reduced hospitalization for heart failure (HFH) or cardiovascular death and delayed renal function decline when added to recommended therapy in patients with heart failure and reduced ejection fraction (HFrEF) in the EMPEROR-Reduced** trial. The EMPEROR-Preserved** trial has now shown that the benefits of empagliflozin extend to patients with heart failure and preserved ejection fraction (HFpEF).

Early and consistent: Breakthrough results in HFpEF similar to HFrEF
14 Jan 2022
HFpEF represents a significant unmet need in CV medicine due to its prevalence, poor prognosis, and the absence of clinically proven therapeutic options. The EMPEROR-Preserved trial demonstrated the continuous clinical benefits in cardiorenal outcomes of empagliflozin in adults with HFpEF, which were consistent with the observations in adults with HFmrEF/ HFpEF in the EMPEROR-reduced trial. The combined results of the EMPEROR trials establish empagliflozin’s efficacy in heart failure regardless of ejection fraction – and if approved, empagliflozin would become the first and only clinically proven therapy to improve outcomes for the full spectrum of the disease. Therefore, empagliflozin offers a new hope for people living with heart failure.
EMPEROR-Preserved: The first successful trial to improve outcomes in HFpEF
18 Nov 2021
Heart failure with preserved ejection fraction (HFpEF) represents a significant unmet medical need. The EMPEROR-Preserved trial aimed to assess the impact of empagliflozin on cardiovascular outcomes in patients with HFpEF. On 27 August 2021, during the hotline session of the 2021 ESC Virtual Congress, the main results of the EMPEROR-Preserved trial were presented by Professor Stefan Anker, principal investigator of the study, and heart failure specialist at Charité Berlin, Germany.
NOACs in nonvalvular atrial fibrillation with multimorbidity: Where does apixaban stand?
02 Nov 2021
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice, affecting millions of people globally. Stroke is one of its devastating complications, with the risk steeply increasing with advancing age. Additionally, AF is associated with more than a tripling of the risk of systemic embolic (SE) events. [J Am Heart Assoc 2020;9:e016724]
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29 Sep 2021
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16 Jun 2021
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Conference Reports
Dapagliflozin DELIVERs across full HF spectrum regardless of LVEF
Elvira Manzano, 04 Oct 2022
The selective, oral sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin reduces the risk of cardiovascular (CV) death or worsening heart failure (HF) in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF or HFpEF) in the phase III DELIVER* trial, touted as the largest and most inclusive thus far in this patient group.
Renal denervation bounces back in 3-year follow-up study
Audrey Abella, 29 Sep 2022
Following negative primary results, the final follow-up of the SYMPLICITY HTN-3 trial takes a turn for the better, demonstrating significant blood pressure (BP) reductions with renal denervation (RDN) in patients with uncontrolled hypertension (HTN).
Antihypertensive dosing TIME does not affect CV outcomes
Roshini Claire Anthony, 26 Sep 2022

Timing of antihypertensive medication intake, be it in the morning or evening, does not appear to affect the risk of cardiovascular death or hospitalization for non-fatal myocardial infarction (MI) or non-fatal stroke, according to results of the TIME trial presented at ESC 2022.

P2Y12 monotherapy wins against aspirin for secondary prevention of CAD
Elaine Soliven, 24 Sep 2022
Compared with aspirin alone, treatment with a P2Y12 inhibitor (clopidogrel or ticagrelor) is associated with lower risks of cardiovascular (CV) death, myocardial infarction (MI), or stroke in patients with established coronary artery disease (CAD), according to the PANTHER* trial presented at ESC 2022.
High-dose quadrivalent flu vax reduces hospitalization, death in older adults
Roshini Claire Anthony, 22 Sep 2022

Older adults who receive a high-dose quadrivalent influenza vaccine have a 49 percent reduced risk of death and a 64 percent reduced risk of hospitalization for influenza or pneumonia compared with those who receive a standard-dose vaccine, results of the DANFLU-1 study showed.

Evolocumab benefits build up in FOURIER OLE
Elvira Manzano, 19 Sep 2022
Early, long-term lipid lowering with the PCSK9 inhibitor evolocumab further reduces cardiovascular (CV) events, including CV death, without any safety signal, in the FOURIER* open-label extension (OLE) study.
Phase II data reveal treatment potential of pegozafermin for severe hypertriglyceridaemia
Audrey Abella, 14 Sep 2022
The phase II ENTRIGUE trial presented at ESC 2022 showed the potential of pegozafermin to improve triglyceride levels and other lipid-related metrics in individuals with severe hypertriglyceridaemia.