Treatment Guideline Chart
Cancer pain is an unpleasant sensory & emotional experience due to actual or potential tissue damage in patients with cancer.
Effective pain management in cancer patients with pain is an essential part of oncologic management due to increasing evidence of survival.
Pancreatic, head & neck cancer has a high prevalence of cancer pain.
During initial evaluation, follow-ups and new therapy initiation of patients with cancer, it is essential that they will be screened & evaluated for pain.

Cancer%20pain Diagnosis


  • All cancer patients should be screened for pain at each contact

Types of Pain

Nociceptive Pain

  • Caused by ongoing tissue damage to somatic and/or visceral structures that results in the activation of nociceptors found in the skin, viscera, muscle and connective tissues
  • Can be subclassified as:
    • Somatic pain that often occur after surgical procedures or from bone metastasis
      • The pain is described as sharp, aching, stabbing, well localized, throbbing and pressure-like
    • Visceral pain is caused by tumor involvement of organ causing pain, may also be due to compression, infiltration or distension of abdominal or thoracic viscera
      • The pain is described as more diffuse and difficult to localize; gnawing or cramping if secondary to obstruction of hollow viscus; aching, sharp or throbbing when due to tumor involvement of organ capsule

Neuropathic Pain

  • Sustained from peripheral or central nervous system damage or dysfunction
  • Pain described as burning, pricking, electric-like, stabbing, sharp or shooting and sometimes may have a deep aching component
  • Pain is usually located in the area innervated by the compressed/damaged peripheral nerve, plexus, nerve root or spinal cord that is often associated with loss of sensation in the painful region
  • Allodynia or dysesthesia may be present
  • Please see Neuropathic Pain disease management chart for further information

Breakthrough Pain

  • Pain that occurs even when pain is adequately treated or even in a relatively well controlled baseline pain
    • It has rapid onset, moderate to severe in intensity and relatively short in duration (median 30 minutes)
  • Rescue doses of short-acting opioids are usually given up to every 3-4 hours given on as-needed basis (10-20% of the 24-hour total of long-acting or regularly scheduled oral opioid dose)
    • Dose may be increased to once an hour on as-needed basis if pain control is inadequate; reassess regimen if hourly dosing is needed for >3 cycles

Incident Pain

  • Pain that occurs after a specific activity or event (eg exercise, physical therapy, routine procedures)
  • Rescue doses of short-acting opioids are given in anticipation of those events
  • Rapidly-acting transmucosal Fentanyl can be considered in opioid-tolerant patients for brief episodes of incident pain not relieved by immediate-release opioids and not caused by inadequate dosing of around-the-clock opioid

End-of-Dose Failure Pain

  • Pain that occurs toward the end of dosing interval for regularly scheduled opioid
  • Regularly scheduled opioid dose or frequency is increased to manage this type of pain

Uncontrolled Persistent Pain

  • Pain that occurs due to inadequate management of existing regularly scheduled opioid
  • Dose schedule adjustment are done to manage this kind of pain


  • In order to manage cancer pain effectively, comprehensive assessment of pain is a necessary first step
  • It is important that the intensity of pain be quantified and qualitatively described by the patient itself whenever possible
  • Aside from using pain rating scale, pain assessment includes:
    • Location, referral pattern, and radiation of pain 
    • Quality of pain: Aching, stabbing, throbbing, or pressure; gnawing, cramping, aching, or sharp pain; burning, tingling, shooting, or electric/shocking pain
    • Timing: Onset, duration, course, persistent or intermittent
    • Presence of breakthrough pain
    • Current and prior non-pharmacologic and pharmacologic treatments used and their impact on pain
    • Adequate comfort, satisfaction with pain relief
    • Provider assessment of adequacy of function
    • Presence of risk factors for undertreatment of pain (eg advanced age, communication barriers, history of substance abuse, cultural factors)
    • Any special issues for the patient relevant to pain treatment
  • Behaviors and discomfort (ie facial expression, body movements, verbalization or vocalizations, changes in interpersonal interactions, changes in routine activity) can also be a way of assessing presence of pain
  • Pain assessment aims to determine:
    • Nature and pathophysiology of pain
    • Pain severity
    • Impact of pain on functions and quality of life
    • Response to interventions
  • Numerical levels of pain intensity or pain scores are:
    • 1-3 is mild
    • 4-6 is moderate
    • 7-10  is severe
  • For nonverbal patients, a multi-faceted approach is recommended, combining direct observation, family/caregiver input, and evaluation of response to pain medicines or non-pharmacologic interventions

Pain Assessment Tools

  • Used in assessing the intensity of pain and the effectiveness of management

Unidimensional Assessment Tools

  • Reliable, easily implemented (with minimal training) and sustained in outpatient practice
  • Numerical rating scale may be done by verbally asking the patient to describe the pain from 0-10 with 10 as the worst pain or by asking the patient to write or encircle the number that describes the intensity of pain experience
  • Categorical scale can be done by asking the patient to give a word or words that describes the pain experience
  • Visual Analogue/Pictorial/Faces Pain rating scale is done by assessing the facial reaction of the patient to pain

Multidimensional Assessment Tools

  • Reliable, but needs more evidence in regards to validity
  • Brief Pain Inventory (BPI) is the most frequently used
    • Assess the severity of pain by its intensity and how it affects the patient’s life
    • Quantifies these measures using a 0 to 10 numerical scale
  • EORTC QLQ-C30 Pain Scale, SF-36 Bodily Pain Scale and the Short Form McGill Pain Questionnaire are other multidimensional scales used

Pain Assessment Tools for Nonverbal Patients

  • Tools that may be used in intubated or unconscious patients
  • Behavioral Pain Scale (BPS) and Critical-Care Pain Observation Tool (CPOT) have been tested in adults and intensive care

Psychosocial Assessment

  • Psychosocial distress assessment should be done as pain is an important stressor in all kinds of cancers that can cause psychological distress and disability
  • Inadequately controlled pain may cause substantial psychological distress
  • Validated tools should be used in screening for psychological distress


  • It is essential to have a good history taking for accurate assessment and diagnosis of causes of pain
  • History should consists of:
    • Characteristics of pain: Location, intensity and frequency
    • Cancer history: Type and staging of carcinoma, chemotherapeutic regimen and duration
    • Medication: Prior treatments received for pain, maintenance treatments
    • Comorbidities
    • Psychosocial status

Physical Examination

  • Confirms the clinical diagnosis formed after comprehensive history taking
  • Gives information on the patient’s condition and extent of problems
  • Neurological exam should be done in all patients especially with suspected neuropathic pain

Laboratory Tests

  • Tumor markers
  • Hepatic and renal clearance


  • Bone scans
  • Magnetic resonance imaging (MRI)
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