Breast cancer is the presence of malignant breast nodule, mass or abscess.
Most common symptom of breast cancer is a new lump or mass in the
breast. The lump or mass is usually painless, hard & irregular but
it can also be tender, soft, rounded or painful.
Other signs & symptoms include breast pain or nipple pain, nipple
discharge, nipple retraction and presence of breast skin changes (eg
peau d' orange, nipple excoriation, scaling, inflammation, skin
tethering, ulceration, abscess).
Annual breast cancer screening with magnetic resonance imaging (MRI) led to detection of fewer late-stage and node-positive cancers than annual mammography, according to the FaMRIsc* study from the Netherlands. However, specificity was lower and number of false-positives higher with MRI vs mammography.
The addition of the CDK* 4/6 inhibitor ribociclib to endocrine therapy significantly extended overall survival (OS) in premenopausal women with HR+ HER2- advanced breast cancer, as evidenced in the phase III MONALEESA-7** trial.
New drug applications approved by US FDA as of 16 - 31 May 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Omitting first-line chemotherapy for patients with metastatic HER2+ breast cancer treated with pertuzumab plus trastuzumab did not affect overall survival (OS) despite shorter progression-free survival (PFS), according to updated results of the phase II PERNETTA* trial.
Adding the selective oestrogen-receptor downregulator fulvestrant to the aromatase inhibitor anastrozole in the first-line setting significantly extends long-term progression-free survival (PFS) and overall survival (OS) compared with anastrozole alone in postmenopausal women with hormone-receptor (HR)-positive metastatic breast cancer, according to the final results of the S0226 trial.
In an exclusive interview with MIMS Doctor, Dr Yong Junina Fadzil, a consultant paediatrician and paediatric cardiologist at Klinik Pakar Kanak-Kanak Junina shared her perspectives on the roles of balanced nutrition and parental influence in child development.
Dr Tan Toh Lick, Consultant Obstetrician and Gynaecologist at Thomson
Women’s Clinic, and Thomson Wellth Clinic Singapore, shares the complexities
of diagnosing polycystic ovarian syndrome in adolescent girls