breast%20cancer
BREAST CANCER
Breast cancer is the presence of malignant breast nodule, mass or abscess.
Most common symptom of breast cancer is a new lump or mass in the breast. The lump or mass is usually painless, hard & irregular but it can also be tender, soft, rounded or painful.
Other signs & symptoms include breast pain or nipple pain, nipple discharge, nipple retraction and presence of breast skin changes (eg peau d' orange, nipple excoriation, scaling, inflammation, skin tethering, ulceration, abscess).

Breast%20cancer Management

Monitoring

Stratification for Systemic Therapy

  • Recommended in early breast cancer
  • May guide in patient selection for chemotherapy addition
  • Patients are further stratified based on responsiveness to endocrine therapy, Trastuzumab and risk for disease recurrence

Categories of Endocrine Responsiveness

Highly Endocrine Responsive

  • Majority of tumor cells express high levels of ER and PR

Incompletely Endocrine Responsive

  • Lower-level expression of ER and/or PR, or absence of either ER or PR

Endocrine Non-responsive

  • Total absence of ER and PR expression
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