breast%20cancer
BREAST CANCER
Breast cancer is the presence of malignant breast nodule, mass or abscess.
Most common symptom of breast cancer is a new lump or mass in the breast. The lump or mass is usually painless, hard & irregular but it can also be tender, soft, rounded or painful.
Other signs & symptoms include breast pain or nipple pain, nipple discharge, nipple retraction and presence of breast skin changes (eg peau d' orange, nipple excoriation, scaling, inflammation, skin tethering, ulceration, abscess).

Monitoring

Stratification for Systemic Therapy

  • Recommended in early breast cancer
  • May guide in patient selection for chemotherapy addition
  • Patients are further stratified based on responsiveness to endocrine therapy, Trastuzumab and risk for disease recurrence

Categories of Endocrine Responsiveness

Highly Endocrine Responsive

  • Majority of tumor cells express high levels of ER and PR

Incompletely Endocrine Responsive

  • Lower-level expression of ER and/or PR, or absence of either ER or PR

Endocrine Non-responsive

  • Total absence of ER and PR expression
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