Asthma is a chronic inflammatory disease of the airways in the lungs of children and adults.
The patient usually complains of shortness of breath, chest tightness and coughing with wheezing.
A diagnosis of asthma in young children is more likely if they have
symptom patterns, presence of risk factors for development of asthma and
therapeutic response to controller treatment.
Goals of treatment are effective symptom control with minimal or no
exacerbations, minimal or no nocturnal and daytime symptoms, no
limitations on activities, minimal or no need for reliever treatment,
and minimal adverse effects of medication.
A self-monitoring application for children with asthma, namely the electronic-AsthmaTracker (e-AT), appears to effectively involve parents in the proactive care of their children, leading to sustained improvement in outcomes, as shown in a recent study.
Dietary intake of the fatty acids (FAs) omega-3 and omega-6 was associated with opposing effects in severity of childhood asthma and susceptibility to environmental pollutants, suggests the AsthmaDIET study.
Extremely premature neonates with cumulative inspired oxygen exposure and frequent intermittent hypoxaemia events during the first 3 days of age are at increased risk of symptomatic childhood wheezing requiring prescription asthma medications, reports a study.
Serum levels of biopterin correlate with the state of the asthma control at follow-up visit in children with stable disease, as shown in a recent study. Therefore, monitoring biopterin levels represent an attractive strategy to assess disease control status and to adjust treatment intensity more precisely.
In children with moderate or severe asthma exacerbations, the presence of respiratory pathogens such as respiratory syncytial virus, influenza and parainfluenza appears to increase the risk of treatment failure, a study reports.
Dupilumab, the fully human anti-interleukin-4 receptor α monoclonal antibody indicated for the treatment of atopic dermatitis, appeared to improve lung function, reduce exacerbations, and decrease oral corticosteroid use in individuals with moderate-to-severe asthma, according to two phase III trials presented at ATS 2018.
Frequent use of antibiotics during pregnancy is associated with an increased risk of childhood asthma, with the risk varies by timing and number of antibiotic courses used during pregnancy, according to a study presented at ATS 2018.
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
The choice between nonvitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) for stroke prevention appears to be complex and largely heterogenous across different, countries, a new study has found.
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Long-term treatment with the interleukin-5
receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.