Treatment Guideline Chart
Anemia is a condition wherein the blood has low levels of red blood cells (RBC), hemoglobin (oxygen-carrying pigment in whole blood) and/or hematocrit (intact RBC in blood) making it insufficient to address the physiologic needs of the body.
Iron-deficiency anemia is the anemia that resulted from inadequate iron supplementation or excessive blood loss.
It is the most common nutritional disorder worldwide and accounts for more than half of anemia cases.
It is prevalent among preschool children and pregnant women.

Anemia - Iron-Deficiency References

  1. Goddard AF, James MW, McIntyre AS, et al. Guidelines for the management of iron deficiency anemia. Gut. 2011;60:1309-1316. doi: 10.1136/gut.2010.228874. Accessed 19 Nov 2014. PMID: 21561874
  2. Pasricha SRS, Flecknoe-Brown SC, Allen KJ, et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust. 2010 Nov;193(9):525-532. Accessed 01 Dec 2014. PMID: 21034387
  3. Schrier SL, Auerbach M. Treatment of the adult with iron deficiency anemia. UpToDate. 17 Nov 2014. Accessed 28 Nov 2014.
  4. Schrier SL. Approach to the adult patient with anemia. UpToDate. 13 Nov 2014. Accessed 21 Nov 2014.
  5. Schrier SL. Causes and diagnosis of iron deficiency anemia in the adult. UpToDate. 20 Aug 2014. Accessed 27 Nov 2014.
  6. Short WM, Domagalski JE. Iron deficiency anemia: evaluation and management. AmFam Physician. 2013;87(2):98-104. Accessed 24 Nov 2014
  7. Bailie GR, Verhoef JJ. Differences in the reporting rates of serious allergic adverse events from intravenous iron by country and population. Clin Adv Hematol Oncol. 2012 Feb;10(2):101-108. Accessed 16 Jun 2015. PMID: 22402351
  8. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015 May;372(19):1832-1843. doi: 10.1056/NEJMra1401038. Accessed 16 Jun 2015. PMID: 25946282
  9. National Blood Authority of Australia. Single unit transfusion guide summary: guidance for Australian health providers. National Blood Authority of Australia. Jun 2014. Accessed 16 Jun 2015.
  10. Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014 Feb;19(2):164-174. PMID: 24778671
  11. Berber I, Diri H, Erkurt MA, et al. Evaluation of ferric and ferrous iron therapies in women with iron deficiency anaemia. Adv Hematol. 2014;2014(297057):1-6. doi: 10.1155/2014/297057. PMID: 25006339
  12. Hathcock JN. Iron. Vitamin and Mineral Safety. Council for Responsible Nutrition (CRN). 3rd ed; 2013. 146-153. :146-153.
  13. Milman N. Anemia – still a major health problem in many parts of the world. Ann Hematol. 2011 Apr;90(4):369-377. doi: 10.1007/s00277-010-1144-5. PMID: 21221586
  14. National Institutes of Health (NIH). Iron – dietary supplement fact sheet. NIH. 2015.
  15. Santiago P. Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical review. Scientific World Journal. 2012. doi: 10.1100/2012/846824. PMID: 22654638
  16. Toblli JE, Brignoli R. Iron (III)-hydroxide polymaltose complex in iron deficiency anemia. Arzneimittelforschung. 2007;57(6A):431-438. Accessed 16 Jun 2015. PMID: 17691593
  17. Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet. 2016 Feb 27;387(10021):907-916. doi: 10.1016/S0140-6736(15)60865-0. Accessed 20 Mar 2017. PMID: 26314490
  18. World Health Organization (WHO). WHO recommendations on antenatal care for a positive pregnancy experience. WHO. Nov 2016. Accessed 15 Feb 2017.
  19. Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J Hematol. 2016 Jan;91(1):31-38. doi: 10.1002/ajh.24201. Accessed 25 Apr 2017. PMID: 26408108
  20. Ford J. Red blood cell morphology. Int J Lab Hematol. 2013 Mar 09;35(3):351-357. doi: 10.1111/ijlh.12082. Accessed 25 Apr 2017
  21. World Health Organization (WHO). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization. (WHO/NMH/NHD/MNM/11.1). WHO. 2011. Accessed 25 Apr 2017.
  22. Toward Optimized Practice Iron Deficiency Anemia Committee. Iron deficiency anemia (IDA) clinical practice guideline. Toward Optimized Practice (TOP). Mar 2018. Accessed 19 Sep 2018.
  23. Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020 Feb;287(2):153-170. doi: 10.1111/joim.13004. Accessed 28 Apr 2020. PMID: 31665543
  24. Pavord S, Daru J, Prasannan N, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020 Mar;188(6):819-830. doi: 10.1111/bjh.16221. Accessed 06 May 2020. PMID: 31578718.
  25. Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr. 2015 Dec;102(6):1585-1594. doi: 10.3945/ajcn.114.103366. PMID: 26561626
  26. Ko CW, Siddique SM, Patel A, et al. AGA clinical practice guidelines on the gastrointestinal evaluation of iron deficiency anemia. Gastroenterology. 2020 Sep;159(3):1085-1094. doi: 10.1053/j.gastro.2020.06.046. PMID: 32810434
  27. World Health Organization (WHO). WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. WHO. 2020. Accessed 14 Apr 2023.
  28. Garzon S, Cacciato PM, Certelli C, et al. Iron deficiency anemia in pregnancy: novel approaches for an old problem. Oman Med J. 2020 Sep;35(5):e166. doi: 10.5001/omj.2020.108. PMID: 32953141
  29. Treating iron deficiency anemia. Australian Red Cross Lifeblood. 2021.
  30. Rockey DC, Altayar O, Falck-Ytter Y, et al. AGA technical review on gastrointestinal evaluation of iron deficiency anemia. Gastroenterology. 2020 Sep;159(3):1097-1119. doi: 10.1053/j.gastro.2020.06.045. PMID: 32828801
  31. Kriplani A, Sharma A, Radhika AG, et al. FOGSI general clinical practice recommendations. Management of iron deficiency anemia in pregnancy. Federation of Obstetric and Gynaecological Societies of India (FOGSI). 15 Jul 2017.
Editor's Recommendations
Special Reports