anaphylaxis%20(pediatric)
ANAPHYLAXIS (PEDIATRIC)

Anaphylaxis is a serious generalized or systemic hypersensitivity reaction that is rapid in onset and potentially fatal.

Diagnosis can be made if it is acute in onset of minute to several hour duration that involves the skin, mucosal tissue or both plus having signs & symptoms either respiratory or cardiovascular compromise.

It involves immunological response with IgE, IgG or immune complexes. Non-immunological mechanisms are also involved and termed as nonallergic anaphylaxis that is relatively uncommon in children.

Protracted, severe anaphylaxis are reactions occurring up to 32 hours despite aggressive management.

 

  1. Cheng A. Emergency treatment of anaphylaxis in infants and children. Paediatr Child Health. 2011 Jan;16(1):35-40. Accessed 25 Jun 2013. PMID: 22211074
  2. Brown SG, Mullins RJ, Gold MS. Anaphylaxis: diagnosis and management. Med J Australia. 2006 Sep;185(5):283-289. http://www.mja.com.au/. Accessed 28 Apr 2010. PMID: 16948628
  3. Kobrynski LJ. Anaphylaxis. Clin Pediatr Emerg Med. 2007;8(2):110-116
  4. Lieberman P, Nicklas RA, Oppenheimer J, et al. The diagnosis and management of anaphylaxis practice parameter: 2010 update. Aug 07, 2010. J Allergy Clin Immunol. 2010 Sep;126(3):477-480.e1-e42. http://www.ncbi.nlm.nih.gov/pubmed/?term=20692689. Accessed 05 Aug 2011. PMID: 20692689
  5. Mace SE, Khan N. Needle cricothyrotomy. Emerg Med Clin North Am. 2008 Nov;26(4):1085-1101. doi: 10.1016/j.emc.2008.09.004. PMID: 19059102
  6. Prescott SL, Tang ML; Australasian Society of Clinical Immunology and Allergy. The Australasian Society of Clinical Immunology and Allergy position statement: summary of allergy prevention in children. Med J Aust. 2005 May;182(9):464-467. http://www.mja.com.au/. Accessed 16 Aug 2011. PMID: 15865590
  7. Salzberg PD, Singer E. Anaphylaxis: when second counts. Emerg Med. 2007;39(5):18
  8. Muraro A, Roberts G, Clark A,et al; EAACI Task Force on Anaphylaxis in Children. The management of anaphylaxis in childhood: position paper of the European Academy of Allergology and Clinical Immunology. Jun 21, 2007. Allergy. 2007 Aug;62(8):857-871. http://www.ncbi.nlm.nih.gov/pubmed/?term=17590200. Accessed 05 Aug 2011. PMID: 17590200
  9. Sampson H, Muñoz-Furlong A, Campbell R, et al. Second symposium on the definition and management of anaphylaxis: summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006 Feb;117(2):391-397. http://www.ncbi.nlm.nih.gov/pubmed/16461139. Accessed 09 Aug 2011. PMID: 16461139
  10. Sampson HA. Anaphylaxis and emergency treatment. Pediatrics. 2003 Jun;111(6 Pt 3):1601-1608. PMID: 12777599
  11. Simons FE. Anaphylaxis in infants: can recognition and management be improved?. Curr Allergy Immunol. 2009 Jun;22(2):67-69. doi: 10.1016/j.jaci.2007.06.025. Accessed 01 Aug 2011. PMID: 17765754
  12. Simons FE. Anaphylaxis: recent advances in assessment and treatment. J Allergy Clin Immunol. 2009 Oct;124(4):625-634. doi: 10.1016/j.jaci.2009.08.025. PMID: 19815109
  13. Simons FE, Ardusso LR, Bilò MB, et al; World Allergy Organization. 2012 Update: World Allergy Organization Guidelines for the assessment and management of anaphylaxis. Curr Opin Allergy Clin Immunol. 2012 Aug;12(4):389-399. doi: 10.1097/ACI.0b013e328355b7e4. PMID: 22744267
  14. Soar J, Pumphrey R, Cant A, et al. Emergency treatment of anaphylactic reactions--guidelines for healthcare providers. Resuscitation. 2008 May;77(2):157-169. doi: 10.1016/j.resuscitation.2008.02.001. PMID: 18358585
  15. Simons FE, Sheikh A. Anaphylaxis: the acute episode and beyond. BMJ. 2013 Feb;346:f602. doi: 10.1136/bmj.f60. PMID: 23403828
  16. National Institute of Allergy and Infectious Diseases (NIAID). Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010 Dec;126(Suppl 6):S1-S58. doi: 10.1016/j.jaci.2010.10.007. Accessed 07 Jun 2011. PMID: 21134576
  17. Cardiac arrest. Merck Manuals Online Medical Library. http://www.merck.com/. Accessed 01 May 2010.
  18. Kemp SF. Anaphylaxis and serum sickness. In: Bope ET, Kellerman R, Rakel RE. Conn's Current Therapy. Philadelphia: Saunders, an imprint of Elsevier; 2010
  19. Sampson HA, Leung D. Anaphylaxis. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of Pediatrics. 18th ed. Philadelphia: Saunders, Elsevier; 2007
  20. Simons FER. Anaphylaxis: An overview of assessment and management. In: Leung DYM, Sampson HA, Geha R, Szefler SJ. Pediatric Allergy: Principles and Practice. 2nd ed. Philadelphia: Elsevier, Saunders; 2010
  21. MedWormhttp://www.medworm.com/rss/index.php/Allergy-%26-Immunology/3/http://www.medworm.com/rss/medicalfeeds/specialities/Allergy-Immunology.xml
  22. MedWormhttp://www.medworm.com/rss/index.php/Pediatrics/33/http://www.medworm.com/rss/medicalfeeds/specialities/Pediatrics.xml
  23. National Institute for Health and Care Excellence. Anaphylaxis: Assessment to confirm an anaphylactic. NICE clinical Guideline 134 episode and the decision to refer after emergency treatment for a suspected anaphylactic episode. NICE. http://www.nice.org.uk/nicemedia/live/13626/57474/57474.pdf. Dec 2011. Accessed 18 Jun 2013
  24. Simons FER, Camargo CA Jr. Rapid recognition and treatment of anaphylaxis. UpToDate. http://www.uptodate.com. 2008. Accessed 28 Apr 2010.
  25. NSW Department of Health, NSW Department of Community Services. Anaphylaxis: guidelines for children’s Services 2007. NSW Health. http://www.community.nsw.gov.au. 2007. Accessed 28 Apr 2010.
  26. Linzer J. Pediatrics, Anaphylaxis. eMedicine. http://emedicine.medscape.com/. 2009. Accessed 28 Apr 2010.
  27. Lieberman P, Kemp S, Oppenheimer J, et al. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol. 2005 Mar;115(3):S483-S523. doi: 10.1016/j.jaci.2005.01.010. PMID: 15753926
  28. Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, Clark AT. BSACI guideline for the diagnosis and management of cow’s milk allergy. Clin Exp Allergy. 2014 May;44(5):642-672. doi: 10.1111/cea.12302. Accessed 25 Jul 2016. PMID: 24588904
  29. Muraro A, Roberts G, Worm M, et al; EAACI Food Allergy and Anaphylaxis Guidelines Group. Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy. 2014 Aug;69(8):1026-1045. http://onlinelibrary.wiley.com/ doi/10.1111/all.12437/pdf. Accessed 28 Oct 2014. PMID: 24909803
  30. Simons FE, Ardusso LR, Bilò MB, et al. International consensus on (ICON) anaphylaxis. World Allergy Organ J. 2014 May;7(1):9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038846/pdf/1939-4551-7-9.pdf. Accessed 28 Oct 2014. PMID: 24920969
  31. Simons FE. Anaphylaxis. J Allergy Clin Immunol. 2008 Feb;121(2):S402-S407. http: //www.ncbi .nlm.nih.gov/pubmed/18241691. PMID: 18241691
  32. Muraro A, Halken S, Arshad SH, et al; EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy. 2014 May;69(5):590-601. doi: 10.1111/all.12398. Accessed 25 Jul 2016. PMID: 24697491
  33. Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis - a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015 Nov;115(5):341-384. doi: 10.1016/j.anai.2015.07.019. PMID: 26505932
  34. Simons FE, Ebisawa M, Sanchez-Borges M, et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J. 2015 Oct;8(1):32. doi: 10.1186/s40413-015-0080-1. PMID: 26525001
  35. Togias A, Cooper SF, Acebal ML, et al. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017 Jan;139(1):29-44. doi: 10.1016/j.jaci.2016.10.010. PMID: 28065278
  36. Ebisawa M, Ito K, Fujisawa T; Committee for Japanese Pediatric Guideline for Food Allergy, The Japanese Society of Pediatric Allergy and Clinical Immunology, The Japanese Society of Allergology. Japanese guidelines for food allergy 2017. Allergol Int. 2017 Apr;66(2):248-264. doi: 10.1016/j.alit.2017.02.001. PMID: 28285847
  37. Recto MST, Genuino MLG, Castor MAR, et al; PSAAI and the PSPGHAN. Dietary primary prevention of allergic diseases in children: the Philippine guidelines. Asia Pac Allergy. 2017 Apr;7(2):102-114. doi: 10.5415/apallergy.2017.7.2.102. PMID: 28487842
  38. Working Group of the Resuscitation Council (UK). Emergency treatment of anaphylactic reactions: Guidelines for healthcare providers. Resuscitation Council UK. http://www.resus.org.uk. Jan 2008 (Reviewed 2016).
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