Anaphylaxis is a serious generalized or systemic hypersensitivity reaction that is rapid in onset and potentially fatal.
Diagnosis can be made if it is acute in onset of minute to several hour
duration that involves the skin, mucosal tissue or both plus having
signs & symptoms either respiratory or cardiovascular compromise.
It involves immunological response with IgE, IgG or immune complexes.
Non-immunological mechanisms are also involved and termed as nonallergic
anaphylaxis that is relatively uncommon in children.
Protracted, severe anaphylaxis are reactions occurring up to 32 hours despite aggressive management.
A large retrospective study from the US, presented at IDWeek 2021, has shown that the Abbott ID NOW rapid molecular COVID-19 assay is highly sensitive and specific at detecting SARS-CoV-2 infection in a paediatric population.
Oral H1-antihistamines are the initial treatment of choice for allergic rhinitis (AR) and chronic urticaria in the primary care setting. However, in a diverse population of patients with AR and urticaria, primary care physicians are faced with the challenge of prescribing the best therapy amid a wide armamentarium of antihistamines available.