anaphylaxis%20(pediatric)
ANAPHYLAXIS (PEDIATRIC)

Anaphylaxis is a serious generalized or systemic hypersensitivity reaction that is rapid in onset and potentially fatal.

Diagnosis can be made if it is acute in onset of minute to several hour duration that involves the skin, mucosal tissue or both plus having signs & symptoms either respiratory or cardiovascular compromise.

It involves immunological response with IgE, IgG or immune complexes. Non-immunological mechanisms are also involved and termed as nonallergic anaphylaxis that is relatively uncommon in children.

Protracted, severe anaphylaxis are reactions occurring up to 32 hours despite aggressive management.

 

Differential Diagnosis

  • Vasovagal (vasodepressor) reaction
    • Condition most commonly confused with anaphylaxis
    • Characterized by absence of bronchospasm and other breathing difficulties, bradycardia (although may occur in anaphylaxis), absence of urticaria
  • Septic or hypovolemic shock
  • Psychiatric disorders (vocal cord dysfunction syndrome, panic attacks)
  • Postprandial syndromes (eg scombroid poisoning)
  • Hereditary angioedema
  • Asthma exacerbation
  • Foreign body aspiration
  • Trauma, child abuse
  • Other cardiovascular or respiratory events
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
13 Oct 2019
Dental care has the potential to reduce the recurrence of severe pneumonia in children with neurologic impairment (NI), whereas gastrostomy tube placement is associated with an increased risk of recurrence, possibly due to unresolved confounding by indication, according to a study.
01 Sep 2019
Guy2Guy, an mHealth HIV prevention programme, is acceptable and feasible for use in young, sexual minority boys, reports a recent study.