anaphylaxis%20(pediatric)
ANAPHYLAXIS (PEDIATRIC)

Anaphylaxis is a serious generalized or systemic hypersensitivity reaction that is rapid in onset and potentially fatal.

Diagnosis can be made if it is acute in onset of minute to several hour duration that involves the skin, mucosal tissue or both plus having signs & symptoms either respiratory or cardiovascular compromise.

It involves immunological response with IgE, IgG or immune complexes. Non-immunological mechanisms are also involved and termed as nonallergic anaphylaxis that is relatively uncommon in children.

Protracted, severe anaphylaxis are reactions occurring up to 32 hours despite aggressive management.

 

Differential Diagnosis

  • Vasovagal (vasodepressor) reaction
    • Condition most commonly confused with anaphylaxis
    • Characterized by absence of bronchospasm and other breathing difficulties, bradycardia (although may occur in anaphylaxis), absence of urticaria
  • Septic or hypovolemic shock
  • Psychiatric disorders (vocal cord dysfunction syndrome, panic attacks)
  • Postprandial syndromes (eg scombroid poisoning)
  • Hereditary angioedema
  • Asthma exacerbation
  • Foreign body aspiration
  • Trauma, child abuse
  • Other cardiovascular or respiratory events
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 Aug 2018
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
07 Sep 2018
Children with Down syndrome appear to have an elevated risk of developing severe respiratory syncytial virus (RSV) infection, a study has found.
Jairia Dela Cruz, 01 Sep 2018
Tight glycaemic control does not yield significant short-term survival gains and risk reductions for infections when compared with a conventional glucose-lowering strategy in critically ill patients in the paediatric intensive care unit, according to a meta-analysis.
01 Oct 2018
Due to varying analyses and reporting methods, fever rates in studies substantially differ. As such, there is a need for standardized fever reporting to allow comparisons between studies, according to a recent investigation.