Dementia is a clinical syndrome characterized by impairment of multiple higher cortical functions that include memory, orientation, thinking, comprehension, calculation, capacity for learning, language, judgment, executive function and visuo-spatial function. It is usually accompanied or preceded by deterioration in emotional control, social behavior or motivation.
Alzheimer's disease is the most common cause of dementia. Sporadic cases usually present after >60 year while familial types are rare and present in <60 year of age (early-onset dementia).
Short-term memory loss is the most common early symptom. Other spheres of cognitive impairment manifest after several years.
An active lifestyle, regardless of vascular risk, may delay the progression of Alzheimer’s disease (AD) by slowing down cognitive decline and neurodegeneration, according to a study presented at the Alzheimer’s Association International Conference (AAIC 2019).
Individuals living within 50 metres of high-voltage overhead power lines tend to have heightened risk of Alzheimer’s dementia or Parkinson’s disease compared with those residing at >600 metres, suggesting that exposure to extremely low-frequency magnetic fields may contribute to an increase in the risk of these neurodegenerative diseases, a study reports.
Individuals who identify as sexual or gender minorities (SGM) appear to be at a higher risk of experiencing subjective cognitive decline (SCD) than individuals who identify as cisgender and heterosexual, according to a study presented at the Alzheimer’s Association International Conference (AAIC 2019).
The use of sleep medications may be associated with the risk of dementia or Alzheimer’s disease (AD) in older adults, according to two studies presented at the recent Alzheimer’s Association International Conference (AAIC 2019).
Continuing education appears to be beneficial in the prevention of mild cognitive impairment or Alzheimer’s-type dementia, with the results of a meta-analysis showing that engaging structured learning activities offered by educational institutions helps increase cognitive reserve.
Biomarkers in the blood may present a new opportunity for developing a simple, noninvasive, and inexpensive screening test for Alzheimer’s disease (AD), according to studies presented at the Alzheimer's Association International Conference (AAIC) 2019.
Sex-specific differences in the way brain regions are connected may influence how tau propagates through the brain and thus, differences in the risk of Alzheimer’s disease between men and women; while participating in the workforce may help stave cognitive decline in women, suggest studies presented at AAIC 2019.
High intake of red meat during midlife was associated with a greater risk of cognitive impairment later in life among Chinese adults, according to data from approximately 20 years of follow-up of the Singapore Chinese Health Study (SCHS) cohort.
Most of older adults in Singapore maintain close relationships with family and/or relative and connect less with friends and neighbours, as reported in a recent study. However, having a larger social support network confers greater protection against the risk of developing dementia as compared with being in the family-dependent social support network type. Meanwhile, there is no significant association between social support network typology and depression.
A new combination product (AXS-07), which consists of the triptan rizatriptan and the NSAID* meloxicam, led to rapid and sustained pain relief than treatment with either component alone or placebo in patients with a history of inadequate response to prior acute migraine treatment, according to data from the MOMENTUM study released during the AAN 2020 Meeting.
While aducanumab significantly reduced clinical decline in individuals with early Alzheimer's disease (AD) in one randomized trial, no changes were seen in another identical study — rendering the role of aducanumab in AD inconclusive.