Dementia is a clinical syndrome characterized by impairment of multiple higher cortical functions that include memory, orientation, thinking, comprehension, calculation, capacity for learning, language, judgment, executive function and visuo-spatial function. It is usually accompanied or preceded by deterioration in emotional control, social behavior or motivation.
Alzheimer's disease is the most common cause of dementia. Sporadic cases usually present after >60 year while familial types are rare and present in <60 year of age (early-onset dementia).
Short-term memory loss is the most common early symptom. Other spheres of cognitive impairment manifest after several years.
Condition demonstrating focal or multifocal (one or more) cognitive domain impairment not normal for age with minimal instrumental activities of daily living (IADLs) impairment and is an intermediate state between normal aging and dementia
Can be the primary manifestation of Alzheimer’s disease (AD) and secondary in other forms of dementia, neurologic disease processes, psychiatric disorder or systemic disease
Amnestic MCI (aMCI) is syndrome where memory dysfunction predominates
Nonamnestic MCI presents as more prominent impairment in other cognitive features (eg executive, language,visuo-spatial)
Patients assessed with MCI has greater risk of progressing to dementia
Encourage these patients to return for re-evaluation in 6-12 months
Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.
Diabetes, hypertension, and older age are associated with lower hospital readmission in patients with gastroparesis, while higher length of stay (LOS), drug abuse, and marijuana use increase the 30-day readmission rate, a study has shown.