alcoholic%20liver%20disease
ALCOHOLIC LIVER DISEASE
Alcoholic liver disease diagnosis is suggested by an established history of habitual alcohol intake of sufficient length and intensity.
Toxic daily threshold of alcohol consumption is 40-80 g for males and 20-40 g for females for 10-12 years.
Signs of alcohol abuse and hepatic injury include malnutrition and muscle wasting, cutaneous telangiectasia, palmar erythema, finger clubbing, Dupuytren's contracture, peripheral neuropathy, parotid gland enlargement and signs of gynecomastia and hypogonadism may also be present.
  1. Mathurin P, Mendenhall CL, Carithers RL Jr, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol. 2002 Apr;36(4):480-487. PMID: 11943418
  2. Arteel G, Marsano L, Mendez C, et al. Advances in alcoholic liver disease. Best Pract Clin Gastroenterol. 2003;17(4):625-647. PMID: 12828959
  3. McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of Gastroenterolology. Am J Gastroenterol. 1998 Nov;93(11):2022-2036. PMID: 9820369
  4. Jamal MM, Morgan TR. Liver disease in alcohol and hepatitis C. Best Pract Clin Gastroenterol. 2003;17(4):649-662. PMID: 12828960
  5. Stewart SF, Day CP. The management of alcoholic liver disease. J Hepatol. 2003;38(Suppl 1):S2-S13. PMID: 12591182
  6. Maher J. Alcoholic Liver Disease. In: Feldman M, Friedman LS, Sleisenger MH, eds. Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. 7th ed. Pennsylvania: Saunders; 2002:1375-1391
  7. MedWormhttp://www.medworm.com/rss/index.php/Gastroenterology/17/http://www.medworm.com/rss/medicalfeeds/specialities/Gastroenterology.xml
  8. Friedman S. Treatment of alcoholic liver disease. UpToDate. http://www.uptodate.com/index. Accessed 19 Sep 2005
  9. European Association for the Study of the Liver. EASL clinical practical guidelines: management of alcoholic liver disease. J Hepatol. 2012 Aug;57(2):399-420. http://www.easl.eu/assets/application/files/5e1b5512fb2cabb_file.pdf. Accessed 20 Feb 2014. PMID: 22633836
  10. O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology. 2010 Jan;51(1):307-328. https://www.aasld.org/practiceguidelines/Documents/Bookmarked%20Practice%20Guidelines/AlcoholicLiverDisease1-2010.pdf. Accessed 20 Feb 2014. PMID: 20034030
  11. Friedman SL. Prognosis and management of alcoholic fatty liver disease and alcoholic cirrhosis. UpToDate. http://www.uptodate.com/. 25 Feb 2014.
  12. Singal AK, Bataller R, Ahn J, et al. ACG clinical guideline: alcoholic liver disease. Am J Gastroenterol. 2018 Feb;113(2):175-194. doi: 10.1038/ajg.2017.469. PMID: 29336434
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