Alcoholic liver disease diagnosis is suggested by an established history of habitual alcohol intake of sufficient length and intensity.
Toxic daily threshold of alcohol consumption is 40-80 g for males and 20-40 g for females for 10-12 years.
Signs of alcohol abuse and hepatic injury include malnutrition and muscle wasting, cutaneous telangiectasia, palmar erythema, finger clubbing, Dupuytren's contracture, peripheral neuropathy, parotid gland enlargement and signs of gynecomastia and hypogonadism may also be present.
Patients with acute-on-chronic liver failure (ACLF) who fulfil both APASL* and EASL** criteria have an elevated risk of liver disease-related mortality, according to a retrospective single-centre study conducted in Singapore. The findings also revealed the factors associated with a poorer prognosis.
Early liver transplantation (LT) should be considered in selected patients with severe alcoholic hepatitis (SAH) as it significantly improves survival with a low impact on the donor pool, according to recent data presented at the Asian Pacific Digestive Week (APDW) 2017 held in Hong Kong.
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.