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acromegaly
ACROMEGALY
Acromegaly is a chronic, slowly developing disease with progressive disfigurement and disability. An early diagnosis is difficult as most signs and symptoms are due to long-standing overproduction of growth hormone &/or insulin-like growth factor (IGF-I) causing metabolic, endocrine and morphological changes.
Surgical intervention is the first-line of treatment for almost all patients with acromegaly unless there are contraindications or the patient refuses to undergo the procedure.
  1. Ben-Shlomo A, Melmed S. Acromegaly. Endocrinol Metab Clin North Am. 2008 Mar;37(1):101-122. PMID: 18226732
  2. Bates B. New acromegaly guidelines target premature, mortality, morbidity. Elsevier Global Medical News. 2009 Feb
  3. Keith E. Acromegaly: a new therapy. Cancer Control. 2002 May;9(3):232-235
  4. Katznelson L, Atkinson JL, Cook DM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Acromegaly - 2011 update. Endocr Pract. 2011 Jul;17(4):1-44. www.aace.com. PMID: 21846619
  5. Lamberts SW. Acromegaly and its treatment. J Endocrinol. 1997 Oct;155(Suppl 1):S49-S51. PMID: 9389995
  6. Giustina A, Barkan A, Casanueva FF, et al. Criteria for the cure of acromegaly: a consensus statement. J Clin Endocrinol Metab. 2000 Feb;85(2):526-529. PMID: 10690849
  7. Melmed C, Casanueva FF, Cavagnini F, et al; Acromegaly Treatment Consensus Workshop Participants. Consensus: guidelines for acromegaly management. J Clin Endocrinol Metab. 2002 Sep;87(9):4054-4058. PMID: 12213843
  8. Liuzzi A, Oppizzi G. Evidence of ocreotide subcutaneously in the treatment of acromegaly. J Endocrinol. 1997 Oct;155(Suppl Suppl 1):S61-S65. PMID: 9389999
  9. Melmed S, Colao A, Barkan A, et al. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009 May;94(5):1509-1517. PMID: 19208732
  10. Stewart PM. Current therapy for acromegaly. Trends Endocrinol Metab. 2000 May;11(4):128-132. PMID: 10754533
  11. Patel YC, Ezzat S, Chik CL, et al. Guidelines for the diagnosis and treatment of acromegaly: a Canadian perspective. Clin Invest Med. 2000 Jun;23(3):172-187. PMID: 10911548
  12. Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000 Apr;342(16):1171-1177. PMID: 10770982
  13. Zaloga GP, Marik P. AACE Medical Guidelines for Clinical Practice for the diagnosis and treatment of acromegaly. Endocr Pract. 2004 May;10(3):213-225. PMID: 15382339
  14. MedWormhttp://www.medworm.com/rss/index.php/Endocrinology/15/http://www.medworm.com/rss/medicalfeeds/specialities/Endocrinology.xml
  15. Khabdwala HM. Acromegaly. eMedicine. http://emedicine.medscape.com/article/116366-overview. May 2005
  16. Melmed S. Treatment of acromegaly. UpToDate. http://www.uptodate.com/contents/treatment-of-acromegaly?detectedLanguage=en&source=search_result&search=Treatment+of+acromegaly&selectedTitle=1~64&provider=noProvider. 2001
  17. Shim M. Gigantism and acromegaly. eMedicine. http://emedicine.medscape.com/article/925446-overview. Mar 2002
  18. The Endocrine Society. Clinical control, anti-tumor and anti-proliferative effects with somatostatin analogues. Medscape. http://www.medscape.org/viewarticle/432080. 2002
  19. MedWormhttp://www.medworm.com/rss/search.php?qu=acromegaly+gigantism&kid=3&t=Acromegaly&f=c&r=Any&news=1http://www.medworm.com/rss/medicalfeeds/conditions/Acromegaly-News.xml
  20. MedWorm - Acromegalyhttp://www.medworm.com/rss/medicalfeeds/conditions/Acromegaly-News.xml
  21. AACE Acromegaly Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly. Endocrine Pract. 2004 May;10(3):213-225.
  22. Melmed S, Jameson JL. Disorders of the anterior pituitary and hypothalamus. In: Jameson JL. Harrison’s Endocrinology. 2nd ed. New York: McGraw-Hill; 2010:16-49.
  23. Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2014 Nov;99(11):3933-3951. doi: 10.1210/jc.2014-2700. PMID: 25356808
  24. Chanson P, Salenave S, Kamenicky P, et al. Pituitary tumors: acromegaly. Best Pract Res Clin Endocrinol Metab. 2009 Oct;23(5):555-574. doi: 10.1016/j.beem.2009.05.010. Accessed 27 Jul 2017. PMID: 19945023
  25. Melmed S. Causes and clinical manifestations of acromegaly. UpToDate. www.uptodate.com. Oct 2015.
  26. Melmed S. Diagnosis of acromegaly. UpToDate. www.uptodate.com. Aug 2015.
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