Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Withdrawal due to adverse events higher with nalmefene

02 Sep 2017

Patients receiving nalmefene to treat impulse control disorders or substance use suffer from a threefold greater risk of withdrawal because of adverse safety events, according to a new meta-analysis.

The meta-analysis included eight randomized controlled trials (RCTs), of which only six reported serious adverse events (SAEs). There was no significant difference in SAE between the nalmefene and placebo groups (Peto odds ratio [POR], 0.97; 95 percent CI, 0.64 to 1.44; p=0.86; risk difference [RD], -0.00; -0.02 to -0.01; p=0.84).

Similarly, the odds for overall psychiatric SAEs were not significantly different between the nalmefene and placebo groups (POR, 1.32; 0.62 to 2.38; p=0.47; RD, 0.00; -0.01 to 0.01; p=0.40). There were also no differences in the risk of depression, anxiety or death.

Pooled findings from all eight RCTs showed that withdrawals due to adverse events were significantly higher in the nalmefene group than in the placebo group (POR, 3.22; 2.46 to 4.22; p<0.00; RD, 0.09; 0.08 to 0.11; p=0.00).

RCTs were included in the meta-analysis if they compared nalmefene to placebo or active controls in patients with impulse control and/or substance use disorders. Those with data on harms were included.

The databases of PubMed, Medline, Embase, Clinicaltrials.gov and the Cochrane Central Register of Controlled Trials were accessed.

Fifteen studies fulfilled the eligibility criteria and only eight were included in the final analysis because of missing harms data. Of the 15 studies, two were still ongoing. The remaining 13 studies corresponded to 3,793 participants.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.