Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
01 Oct 2015
The earliest evidence of rheumatic heart disease (RHD) in children increases the risk of acute rheumatic heart disease, valvular lesion progression and definite RHD development as stated in a prospective cohort study.

Weight gain, dyslipidaemia, hypertension common after adjuvant chemo for breast cancer

02 Sep 2017

Hypertension, dyslipidaemia and an abnormal 60-percent increase in body mass index (BMI) are common complications in premenopausal breast cancer patients who have received adjuvant chemotherapy, a recent study in a Chinese population has found.

The study included 280 breast cancer patients (median age 46.5 years), of which 88 had stage I, 165 had stage II and 27 had stage III. Oestrogen receptor (ER)-positive cancers were observed in 73 percent, progesterone receptor (PR)-positive in 67 percent and HER2-positive in 17 percent.

At study entry, 63.2 percent (n=177) experienced >2 percent weight gain since breast cancer diagnosis. Of these, 121 had a weight gain of 5 percent.

Multivariate analysis showed that taxane-containing chemotherapies (odds ratio [OR], 2.041; 95 percent CI, 1.127 to 3.696; p=0.0186) and chemotherapy-related amenorrhoea (CRA; OR, 3.472; 1.395 to 8.621; p=0.0074) were independent factors for weight gain >2 percent.

Of the participants, 30.7 percent (n=86) were hypertensive, 13.2 percent (n=37) had elevated systolic blood pressure (SBP) and 3.9 percent (n=11) had elevated diastolic blood pressure (DBP). SBP and DBP were elevated in 13.6 percent (n=38).

Overweight or obesity at study entry (OR, 2.723; 1.568 to 4.728; p=0.0004) and ER-positivity (OR, 0.552; 0.311 to 0.980; p=0.0423) were significantly related to hypertension.

In terms of fasting serum lipid levels, 34.3 percent (n=93) had high total cholesterol, 56.1 percent (n=152) had high low-density lipoprotein cholesterol (LDL-C), 6.6 percent (n=18) had high high-density lipoprotein cholesterol (HDL-C) and 22.9 percent (n=62) had hypertriglyceridemia.

Overweight or obesity at study entry was a consistent significant factor for high total cholesterol (OR, 1.764; 1.013 to 3.073; p=0.0451), high LDL-C (OR, 2.560; 1.410 to 4.649; p=0.0020), high HDL-C (OR, 7.786; 1.742 to 34.795; p=0.0072) and high triglyceride (OR, 2.775; 1.446 to 5.325; p=0.0021).

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Most Read Articles
01 Mar 2016
The present understanding on the pathogenesis, diagnosis, and management of rheumatic heart disease were discussed in a review.
05 Jun 2015
Acute rheumatic fever and rheumatic heart disease continue to cause serious problems and hospitalisations according to a study in Zimbabwe.
03 Jun 2017
Both high and low values of the atherogenic index of plasma are independently associated with all-cause mortality, a new study reveals.
01 Oct 2015
The earliest evidence of rheumatic heart disease (RHD) in children increases the risk of acute rheumatic heart disease, valvular lesion progression and definite RHD development as stated in a prospective cohort study.