Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.

Weight gain, dyslipidaemia, hypertension common after adjuvant chemo for breast cancer

02 Sep 2017

Hypertension, dyslipidaemia and an abnormal 60-percent increase in body mass index (BMI) are common complications in premenopausal breast cancer patients who have received adjuvant chemotherapy, a recent study in a Chinese population has found.

The study included 280 breast cancer patients (median age 46.5 years), of which 88 had stage I, 165 had stage II and 27 had stage III. Oestrogen receptor (ER)-positive cancers were observed in 73 percent, progesterone receptor (PR)-positive in 67 percent and HER2-positive in 17 percent.

At study entry, 63.2 percent (n=177) experienced >2 percent weight gain since breast cancer diagnosis. Of these, 121 had a weight gain of 5 percent.

Multivariate analysis showed that taxane-containing chemotherapies (odds ratio [OR], 2.041; 95 percent CI, 1.127 to 3.696; p=0.0186) and chemotherapy-related amenorrhoea (CRA; OR, 3.472; 1.395 to 8.621; p=0.0074) were independent factors for weight gain >2 percent.

Of the participants, 30.7 percent (n=86) were hypertensive, 13.2 percent (n=37) had elevated systolic blood pressure (SBP) and 3.9 percent (n=11) had elevated diastolic blood pressure (DBP). SBP and DBP were elevated in 13.6 percent (n=38).

Overweight or obesity at study entry (OR, 2.723; 1.568 to 4.728; p=0.0004) and ER-positivity (OR, 0.552; 0.311 to 0.980; p=0.0423) were significantly related to hypertension.

In terms of fasting serum lipid levels, 34.3 percent (n=93) had high total cholesterol, 56.1 percent (n=152) had high low-density lipoprotein cholesterol (LDL-C), 6.6 percent (n=18) had high high-density lipoprotein cholesterol (HDL-C) and 22.9 percent (n=62) had hypertriglyceridemia.

Overweight or obesity at study entry was a consistent significant factor for high total cholesterol (OR, 1.764; 1.013 to 3.073; p=0.0451), high LDL-C (OR, 2.560; 1.410 to 4.649; p=0.0020), high HDL-C (OR, 7.786; 1.742 to 34.795; p=0.0072) and high triglyceride (OR, 2.775; 1.446 to 5.325; p=0.0021).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.