Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
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Wear rate slower in crosslinked than conventional polyethylene for total hip arthroplasty

12 Jul 2017
MHRA's experts found that soft tissue necrosis may occur even in patients who were not showing any symptoms such as hip pain or swelling; therefore it issued the new guidance, aimed at doctors.

First-generation crosslinked polyethylene is more resistant to wear than conventional polyethylene during the first 13 years after total hip arthroplasty (THA), a new randomized controlled trial (RCT) follow-up reveals.

In 16 patients who were followed up for 13 years following THA, the yearly wear rate of the crosslinked polyethylene (n=8; 0.04±0.02 mm/year) was significantly lower than the conventional polyethylene (n=8; 0.08±0.03 mm/year; p=0.007).

Similarly, femoral head penetration in the conventional polyethylene group (1.046 mm; 0.549 to 1.428) was significantly higher than in the crosslinked polyethylene group (0.622; 0.361 to 1.037; p=0.013).One case of osteolysis was reported in the conventional polyethylene group. At 13.7 years, the femoral head penetration was 1.4 mm and the wear rate was 0.104 mm/year.

In terms of clinical outcomes, there were no significant differences between the two groups. Mean Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores at 13 years in the crosslinked and conventional polyethylene were comparable to each other (69.2 vs 67.9; p=0.92).

Similarly, corresponding scores in the Harris Hip Score (85.6 vs 89.5; p=0.51) and SF-12 mental score (57.5 vs 54.2; p=0.45) indices were not significantly different from each other.

Patients were from an initial prospective RCT including 100 THA patients randomized to receive either conventional polyethylene (n=50) or crosslinked polyethylene (n=50). The current cohort consists of 16 of the original patients who returned for radioisometric analysis and clinical outcome assessment after 13 years.

The current cohort had a mean duration of 13.6 years since implantation, a mean BMI of 28.4 kg/m2 and a mean age of 67.5 years at the time of the procedure. There were no significant demographic differences between the two polyethylene groups.

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
5 days ago
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.
4 days ago
The size and shape of a person’s face may predict sex drive and intended infidelity, research has shown.