Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Voriconazole may increase risk for squamous cell carcinoma in allogeneic HCT patients

09 Oct 2017

Use of voriconazole appears to increase the risk specifically for squamous cell carcinoma (SCC) in the allogeneic haematopoietic cell transplantation (HCT) population, according to a recent study.

To examine the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcinoma, researchers conducted a retrospective cohort study involving 1,220 individuals who had undergone allogeneic HCT and 1,418 who had undergone autologous HCT. Voriconazole exposure and other known risk factors for NMSC were included in multivariate analysis.

Multivariate analyses revealed that using voriconazole elevated the risk for NMSC (hazard ratio [HR], 1.82; 95 percent CI, 1.13 to 2.91) among patients who had undergone allogeneic HCT, particularly for SCC (HR, 2.25; 1.30 to 3.89). In patients who had undergone autologous HCT, using voriconazole did not contribute to an increased risk for NMSC.

In an earlier study, Wojenski and colleagues identified cumulative days of voriconazole use as a predictor of SCC development following allogeneic HCT. This information, according to them, may help guide appropriate antifungal use in this patient population. [Transpl Infect Dis 2015;17:250-8]

Meanwhile, a study by Boast and colleagues on voriconazole dosing and therapeutic drug monitoring (TDM) in children found a significant intra- and interindividual variability in voriconazole concentrations in children, particularly those <6 years of age, which warranted repeated TDM throughout treatment. The authors also recommended standardized guidelines for TDM and dose adjustment in children. [J Antimicrob Chemother 2016;71:2031-6]

The current study is limited by its retrospective design, according to researchers, adding that voriconazole has previously been tied to an increased risk for cutaneous SCC in solid organ transplant recipients.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.