Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Vitamin D reduces pain, infections in palliative cancer patients

6 days ago

Vitamin D supplementation in palliative cancer patients improves pain in the first month and reduces infections in the third month after treatment, a new matched case-control study has shown. Moreover, vitamin D supplementation appears to be safe and well tolerated.

In the study, 39 palliative cancer patients (mean age 62±13 years; 21 females) were given vitamin D supplements per day and showed significantly lower baseline quality of life (QoL), as measured by the Edmonton Symptom Assessment Scale (ESAS), compared with 39 matched untreated controls (5.5 vs 4.1; p=0.02).

ESAS QoL showed slight improvements in the vitamin D group (adjusted mean difference [MD], -1.4; 95 percent CI, -2.6 to -0.21) 1 month after treatment, which resulted in an insignificant difference between the two groups.

Higher number of days on antibiotic therapy in the vitamin D group and a corresponding shorter antibiotic duration in controls led to a decreasing trend of infections in the vitamin D group 1 month after treatment. At 3 months, infections were significantly lower in the vitamin D group than in controls (adjusted MD, -26 percent; -41 to -12 percent).

Vitamin D supplementation did not cause unwanted and adverse side effects, such as hypercalcaemia, in the cancer patients.

All patients enrolled were adults, had incurable cancers regardless of type and serum 25-OHD levels <75 nmol/L. Controls were matched according to age, sex, cancer type and 25-OHD level and were taken from a previous observational study at the same ward. Vitamin D3 supplements (cholecalciferol) were administered at a dose of 4,000 IE per day.

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Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.