Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.

Vitamin D reduces anti-dsDNA positivity in systemic lupus erythematosus

25 Jul 2017
Vitamin D supplementation decreases positivity to anti-double stranded (ds) DNA in systemic lupus erythematosus (SLE), according to a new meta-analysis.

A meta-analysis of three studies (intervention group, n=233; placebo, n=128) that evaluated the positivity to anti-dsDNA in SLE showed that vitamin D supplementation resulted in a significant drop in anti-dsDNA positivity (risk difference, -0.10; 95 percent CI, -0.18 to -0.03; p=0.005).

After 6 months of vitamin D supplementation, the following fatigue measurements in SLE showed significant improvements: fatigue interfering with social life (p=0.01), fatigue considered a problem (p=0.03), fatigue from medium effort (p=0.02), fatigue easily (p=0.003) and fatigue when performing exercise (p=0.03).

On the other hand, in rheumatoid arthritis (RA), vitamin D did not have significant effects on the visual analogue scale (VAS; mean difference, 2.79; -1.87 to 7.44; p=0.24) or on the disease activity score 28 (DAS-28; mean difference, -0.31; -0.86 to 0.25; p=0.28), according to an analysis of two studies (intervention, n=61; placebo, n=59).

Two other studies (intervention, n=124; placebo, n=128) showed that RA recurrence decreased although insignificantly (mean difference, -0.10; -0.21 to 0.00; p=0.05).

The meta-analysis included seven randomized controlled trials that investigated the effects of vitamin D supplementation on adult participants with immune-mediated rheumatic diseases. Those with exclusively bone metabolism or cardiovascular endpoints were excluded.

The databases of Medline, Embase, Lilacs, CINAHL and Cochrane were accessed for this meta-analysis.

Quality of the studies was measured from the following criteria: query of the study, randomization, blinding, concealment, participant attrition, homogeneity, outcome measures and intention-to-treat analysis. All studies had a high risk of bias for at least one of the aforementioned criteria.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.