Most Read Articles
3 years ago

Over the past few decades, there has been widespread concern about the increasing proportion of births born by caesarean delivery. The rising rate of primary caesarean section has led to the increased number of obstetric population with a history of prior caesarean delivery. Although this group of women may be offered planned vaginal birth after previous caesarean section (VBAC) or elective repeat caesarean section (ERCS), the VBAC rate is generally low particularly in well-developed countries. In the United States, the VBAC rate has decreased to 8.5% by 2006, while the total caesarean rate has increased to 31.1%.1

Kavitha G. Shekar, 2 years ago

Doppler measurement of cerebroplacental ratio (CPR) can detect chronic placental insufficiency and failure to reach growth potential (FRGP) in appropriate-for-gestational age (AGA) pregnancies. This allows to time delivery of pregnancies, except monochorionic pregnancy, says Dr Tony Tan from the Department of Obstetrics and Gynaecology, Raffles Hospital, Singapore.

2 years ago
As evaluated in a randomised, controlled study on three-year leuprorelin acetate treatment with tamoxifen, it is as safe and effective as two-year therapy in premenopausal, endocrine-responsive breast cancer patients.
2 years ago
Psychiatric symptoms may be correlated with functional impairment in patients with chronic pelvic pain based on a study.

Vitamin D deficiency linked to preterm births

3 months ago

Vitamin D insufficiency is associated with the risk of preterm births, a new meta-analysis reports. However, there is little evidence to link stillbirths and spontaneous abortions to vitamin D levels.

PubMed and Scopus were searched for original, longitudinal epidemiologic studies regarding vitamin D status and adverse pregnancy outcomes. Only those conducted in humans and those that assessed vitamin D levels through laboratory methods were included.

Studies involving nonsingleton pregnancies and mothers with conditions like HIV and pre-eclampsia were excluded. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies selected.

A total of 18 studies were included. Of these, eight were of very high quality, three had high quality, four had satisfactory quality and three had low quality. Because vitamin D levels were measured through laboratory techniques, the risk of information bias was low.

There was an 83-percent (95 percent CI, 1.23 to 2.74) increased risk of preterm births at <32 to 34 weeks and a 13-percent increased risk (0.94 to 1.36) at <35 to 37 weeks associated with serum 25(OH)D levels <75 nmol/l.

Decreasing levels of serum 25(OH)D was associated with significant increases in the risk of preterm births (50 to 75 nmol/l: summary relative risk [RR].1.25; 1.04 to 1.49; <50 nmol/l: summary RR, 1.36; 1.04 to 1.78).Furthermore, an 11-percent increased risk of spontaneous preterm births at <35 to 37 weeks was associated with serum 25(OH)D levels of<75 nmol/l (RR, 1.11; 0.75 to 1.65).

The risk of stillbirths (RR, 1.02; 0.96 to 1.09), spontaneous abortions (RR, 1.04; 0.95 to 1.13), short gestational lengths (effect size [ES], -0.24; -0.69 to 0.22) and low Apgar scores were not associated with vitamin D insufficiency.

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Most Read Articles
3 years ago

Over the past few decades, there has been widespread concern about the increasing proportion of births born by caesarean delivery. The rising rate of primary caesarean section has led to the increased number of obstetric population with a history of prior caesarean delivery. Although this group of women may be offered planned vaginal birth after previous caesarean section (VBAC) or elective repeat caesarean section (ERCS), the VBAC rate is generally low particularly in well-developed countries. In the United States, the VBAC rate has decreased to 8.5% by 2006, while the total caesarean rate has increased to 31.1%.1

Kavitha G. Shekar, 2 years ago

Doppler measurement of cerebroplacental ratio (CPR) can detect chronic placental insufficiency and failure to reach growth potential (FRGP) in appropriate-for-gestational age (AGA) pregnancies. This allows to time delivery of pregnancies, except monochorionic pregnancy, says Dr Tony Tan from the Department of Obstetrics and Gynaecology, Raffles Hospital, Singapore.

2 years ago
As evaluated in a randomised, controlled study on three-year leuprorelin acetate treatment with tamoxifen, it is as safe and effective as two-year therapy in premenopausal, endocrine-responsive breast cancer patients.
2 years ago
Psychiatric symptoms may be correlated with functional impairment in patients with chronic pelvic pain based on a study.