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Vitamin D deficiency linked to preterm births

20 Mar 2017

Vitamin D insufficiency is associated with the risk of preterm births, a new meta-analysis reports. However, there is little evidence to link stillbirths and spontaneous abortions to vitamin D levels.

PubMed and Scopus were searched for original, longitudinal epidemiologic studies regarding vitamin D status and adverse pregnancy outcomes. Only those conducted in humans and those that assessed vitamin D levels through laboratory methods were included.

Studies involving nonsingleton pregnancies and mothers with conditions like HIV and pre-eclampsia were excluded. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies selected.

A total of 18 studies were included. Of these, eight were of very high quality, three had high quality, four had satisfactory quality and three had low quality. Because vitamin D levels were measured through laboratory techniques, the risk of information bias was low.

There was an 83-percent (95 percent CI, 1.23 to 2.74) increased risk of preterm births at <32 to 34 weeks and a 13-percent increased risk (0.94 to 1.36) at <35 to 37 weeks associated with serum 25(OH)D levels <75 nmol/l.

Decreasing levels of serum 25(OH)D was associated with significant increases in the risk of preterm births (50 to 75 nmol/l: summary relative risk [RR].1.25; 1.04 to 1.49; <50 nmol/l: summary RR, 1.36; 1.04 to 1.78).Furthermore, an 11-percent increased risk of spontaneous preterm births at <35 to 37 weeks was associated with serum 25(OH)D levels of<75 nmol/l (RR, 1.11; 0.75 to 1.65).

The risk of stillbirths (RR, 1.02; 0.96 to 1.09), spontaneous abortions (RR, 1.04; 0.95 to 1.13), short gestational lengths (effect size [ES], -0.24; -0.69 to 0.22) and low Apgar scores were not associated with vitamin D insufficiency.

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Most Read Articles
Dr. Joslyn Ngu, 26 May 2015
Lower oestrogen levels during menopause is associated with lower risk of breast cancer but higher risk of osteoporosis and potentially Alzheimer’s disease (AD), metabolic syndrome and cardiovascular disease, says an expert.
Audrey Abella, 31 Jan 2017
Vitamin B12 deficiency is prevalent during pregnancy and was linked to preterm birth and lower birth weight, a recent study found.
12 Apr 2017
CANESTEN HC – Clotrimazole 1% w/w and hydrocortisone 1% w/w cream – Bayer
09 Feb 2017
In patients undergoing caesarean section (CS) or vaginal delivery (VD), the intravenous administration of tranexamic acid (TA) appears to be safe and effective in reducing blood loss and the need for blood transfusion. In addition, it may decrease the occurrence of postpartum haemorrhage (PPH) in CS patients, according to a systematic review and meta-analysis.