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Vitamin D deficiency linked to preterm births

20 Mar 2017

Vitamin D insufficiency is associated with the risk of preterm births, a new meta-analysis reports. However, there is little evidence to link stillbirths and spontaneous abortions to vitamin D levels.

PubMed and Scopus were searched for original, longitudinal epidemiologic studies regarding vitamin D status and adverse pregnancy outcomes. Only those conducted in humans and those that assessed vitamin D levels through laboratory methods were included.

Studies involving nonsingleton pregnancies and mothers with conditions like HIV and pre-eclampsia were excluded. The Newcastle-Ottawa Scale was used to evaluate the methodological quality of the studies selected.

A total of 18 studies were included. Of these, eight were of very high quality, three had high quality, four had satisfactory quality and three had low quality. Because vitamin D levels were measured through laboratory techniques, the risk of information bias was low.

There was an 83-percent (95 percent CI, 1.23 to 2.74) increased risk of preterm births at <32 to 34 weeks and a 13-percent increased risk (0.94 to 1.36) at <35 to 37 weeks associated with serum 25(OH)D levels <75 nmol/l.

Decreasing levels of serum 25(OH)D was associated with significant increases in the risk of preterm births (50 to 75 nmol/l: summary relative risk [RR].1.25; 1.04 to 1.49; <50 nmol/l: summary RR, 1.36; 1.04 to 1.78).Furthermore, an 11-percent increased risk of spontaneous preterm births at <35 to 37 weeks was associated with serum 25(OH)D levels of<75 nmol/l (RR, 1.11; 0.75 to 1.65).

The risk of stillbirths (RR, 1.02; 0.96 to 1.09), spontaneous abortions (RR, 1.04; 0.95 to 1.13), short gestational lengths (effect size [ES], -0.24; -0.69 to 0.22) and low Apgar scores were not associated with vitamin D insufficiency.

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Most Read Articles
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.
5 days ago
Elagolix is safe and effective for reducing heavy menstrual bleeding in females with fibroids, a new dose-ranging, multiple-cohort study has shown.
13 Oct 2017
Dr Joon Kiong Lee discusses pharmacotherapy for osteoporosis and the role of FLS in fracture prevention
Tristan Manalac, 06 Oct 2017
In women with polycystic ovary syndrome (PCOS), combined oral contraceptive (COC) with spironolactone is more effective than metformin in reducing symptoms while showing a similar safety profile, according to a new randomized clinical trial (RCT).