Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Vitamin D deficiency, insufficiency may increase risk of CV events

17 Jul 2017

Both insufficiency and deficiency in vitamin D are linked to subclinical atherosclerosis, which potentially suggests an elevated cardiovascular (CV) risk, according to a recent study.

Researchers systematically searched PubMed, Web of Science Scopus and Embase databases for studies assessing the impact of vitamin D deficiency on common carotid artery intima-media thickness (CCA-IMT) and prevalence of carotid plaques, which are markers of subclinical atherosclerosis and predictors of CV events.

A total of 21 studies (3,777 vitamin D-deficient patients and 4,792 controls) with data on CCA-IMT and six studies (1,889 vitamin D-deficient patients and 2,883 controls) on the prevalence of carotid plaques met the inclusion criteria.

There was significantly higher CCA-IMT (mean difference [MD], 0.043 mm; 95 percent CI, 0.030 to 0.056; p<0.001) and an increased prevalence of carotid plaques (odds ratio [OR], 2.29; 1.03 to 5.11; p=0.043) with an attributable risk of 35.9 percent among patients with vitamin D deficiency compared with controls.

When selecting for studies specifically including patients with diabetes, those with vitamin D deficiency showed higher prevalence of carotid plaques than controls (OR, 3.27; 1.62 to 6.62; p=0.001). There was a significant difference in CCA-IMT when comparing vitamin D-insufficient patients with controls (MD, 0.011; 0.010 to 0.012; p<0.001).

Results were substantially confirmed by sensitivity analyses, while regression models demonstrated that all of the other clinical and demographic covariates—with the exception of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and the prevalence of hypercholesterolemia—significantly impacted on the difference in CCA-IMT between vitamin D-deficient patients and controls

Patients with vitamin D deficiency have an increased CV morbidity and mortality, according to researchers.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.