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Vismodegib use ups risk of subsequent squamous cell carcinoma

08 Oct 2017
Skin cancer is among the top 10 cancers for men and women in Singapore

Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.

“Vismodegib is a first-in-class agent targeting the hedgehog signaling pathway for treatment of patients with locally advanced BCC and metastatic BCC,” researchers explained.

Researchers performed a retrospective cohort study to decide whether use of vismodegib is associated with an increase in the risk of cutaneous SCC. They compared patients who received vismodegib as part of phase I and II clinical studies with participants from the University of California, San Francisco, Nonmelanoma Skin Cancer Cohort who were treated with standard therapy for primary BCC.

A total of 1,675 patients were included in the analysis. The authors evaluated the development of SCC after treatment with vismodegib.

Results showed that use of vismodegib did not correlate with a heightened risk of subsequent development of SCC (adjusted hazard ratio, 0.57; 95 percent CI, 0.28 to 1.16). On the other hand, the development of SCC was significantly associated with covariates, such as age, sex, history of previous nonmelanoma skin cancer and number of visits per year.

This study was limited by the use of a historic control cohort as a comparator, according to researchers.

In an earlier study by Mohan and colleagues, findings showed that vismodegib use increased the risk of developing a non-BCC malignancy, most of which were cutaneous squamous cell carcinomas. This highlighted the importance of continued skin surveillance after initiation of the said therapy. [JAMA Dermatol 2016;152:527-32]

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.