Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.

Vismodegib use ups risk of subsequent squamous cell carcinoma

08 Oct 2017
Skin cancer is among the top 10 cancers for men and women in Singapore

Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.

“Vismodegib is a first-in-class agent targeting the hedgehog signaling pathway for treatment of patients with locally advanced BCC and metastatic BCC,” researchers explained.

Researchers performed a retrospective cohort study to decide whether use of vismodegib is associated with an increase in the risk of cutaneous SCC. They compared patients who received vismodegib as part of phase I and II clinical studies with participants from the University of California, San Francisco, Nonmelanoma Skin Cancer Cohort who were treated with standard therapy for primary BCC.

A total of 1,675 patients were included in the analysis. The authors evaluated the development of SCC after treatment with vismodegib.

Results showed that use of vismodegib did not correlate with a heightened risk of subsequent development of SCC (adjusted hazard ratio, 0.57; 95 percent CI, 0.28 to 1.16). On the other hand, the development of SCC was significantly associated with covariates, such as age, sex, history of previous nonmelanoma skin cancer and number of visits per year.

This study was limited by the use of a historic control cohort as a comparator, according to researchers.

In an earlier study by Mohan and colleagues, findings showed that vismodegib use increased the risk of developing a non-BCC malignancy, most of which were cutaneous squamous cell carcinomas. This highlighted the importance of continued skin surveillance after initiation of the said therapy. [JAMA Dermatol 2016;152:527-32]

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Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.