Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.

Viscous budesonide ranks as most effective therapy for EoE in meta-analysis

07 Sep 2017

Viscous budesonide appears to be the most effective pharmacologic therapy for eosinophilic esophagitis (EoE) among several pharmacologic treatments, including budesonide suspension, fluticasone, prednisone, esomeprazole and mepolizumab, according to the results of a network meta-analysis.

Researchers searched multiple electronic databases for studies evaluating pharmacologic treatments for EoE and performed a random-effects network meta-analysis to identify the most effective therapy, with the ranking probability for the efficacy of each treatment analysed. A subgroup analysis was also carried out among studies that excluded gastroesophageal reflux disease or proton pump inhibitor therapy-responsive oesophageal eosinophilia, and among studies conducted in paediatric and adult populations.

A total of 11 studies involving 456 patients and comparing six pharmacologic treatments (budesonide suspension and viscous, fluticasone, prednisone, esomeprazole, and mepolizumab) against placebo were included in the analysis.

Pooled data demonstrated the superiority of budesonide viscous, budesonide suspension and fluticasone over placebo. The rank order of efficacy among the reported pharmacologic treatments was as follows: budesonide viscous, esomeprazole, prednisone, budesonide suspension, fluticasone, mepolizumab and placebo.

Results were robust on inconsistency model analysis and node-splitting analysis.

In the subgroup analysis, prednisone was the most effective among studies that excluded gastroesophageal reflux disease or proton pump inhibitor-responsive oesophageal eosinophilia. On the other hand, budesonide suspension and esomeprazole were the most effective pharmacologic treatments and among studies in paediatric and adult populations, respectively.

Additional comparative studies, especially among different topical steroid therapies, are warranted to confirm the present data, researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.