Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

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VCE, CTE both useful in diagnosis of small bowel bleeding

31 Jul 2017

Both video capsule endoscopy (VCE) and computed tomography enterography (CTE) complement each other in the diagnosis of potential small bowel (SB) bleeding, suggests a recent study. Clinicians should consider CTE when VCE is negative.

In addition, severe bleeding and age <40 years independently predict a higher diagnostic yield for CTE, according to researchers.

In this study that compared the efficacy of VCE with CTE and identified factors predictive of a high diagnostic yield for CTE, the authors prospectively enrolled consecutive patients with potential SB bleeding. Participants underwent VCE and CTE within a 1-week interval.

Surgery or enteroscopy was utilized to achieve definitive diagnoses, except when a strategy of VCE and conservative management was suitable. Researchers then measured diagnostic yields and sensitivities of each investigation.

Of the 52 patients (41 with overt and 11 with occult bleeding) recruited in the study, 36 received a definitive diagnosis. The corresponding diagnostic yields and sensitivities were 59.6 and 30.8 percent (p=0.004) for VCE, and 72.2 and 44.4 percent (p=0.052) for CTE.

The combined sensitivity of VCE and CTE was 88.9 percent, which is significantly greater than VCE (p=0.03) or CTE (p<0.01) alone. VCE was better for ulcers, enteritis and angiodysplasia, while CTE was better for tumours and Meckel diverticula.

Age <40 years (odds ratio [OR], 7.3; 95 percent CI, 1.04 to 51.4; p=0.046) and severe bleeding (OR, 6.1; 1.4 to 25.5; p=0.014) were independent predictors of a higher diagnostic yield for CTE.

“In potential SB bleeding, CTE potentially detects some lesions missed by VCE, but few data have determined its clinical utility,” according to researchers.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.