Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Varying concentrations of alcohol do not alter pharmacokinetics of amphetamine

31 Aug 2017

Alcohol concentrations of between 4 and 40 percent appear to have no significant effect on the pharmacokinetic profile of the psychostimulant amphetamine, a study has found.

The phase I single-dose, open-label study included 32 healthy adults. Participants were randomized to receive amphetamine extended-release orally disintegrating tablet (AMP XR-ODT; 18.8 mg) in one of four sequences: following 240 mL of deionized water or 4, 20 or 40 percent ethanol. Blood samples were collected, and the pharmacokinetic profiles of d- and l-AMP were compared across treatment groups.

No change was seen in the extent of absorption for d- or l-AMP with alcohol coingestion. Moreover, there was no dose-dumping of the extended-release portion of the drug formulation.

The 90 percent CIs for the geometric mean ratios for Cmax (peak serum concentration the drug achieves in a specified test area of the body) and systemic exposure (area under the curve [AUC0]–5, AUClast and AUC0–∞) were in the range of 80 to 125 percent.

Adverse events were mild to moderate in severity, consistent with the known adverse event profile for AMP XR-ODT or alcohol.

The present data are relevant to clinicians who have concerns about alcohol use and/or abuse when treating attention deficit hyperactivity disorder (ADHD), researchers said.

Characterized by inattention, impulsivity and hyperactivity, ADHD can lead to alcohol and other drug (AOD)-related problems. In previous studies, it was shown that the mental disorder contributes to the development of AOD use disorders. The potential role of ADHD in the development of AOD use problems is said to have important implications for prevention and treatment of such problems. [Alcohol Res Health 2002;26:122-129]

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.