Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Upcoming expiratory pressure device may help reduce infection in cystic fibrosis

Roshini Claire Anthony
17 Jan 2017

An upcoming disposable positive expiratory pressure (PEP) device for individuals with cystic fibrosis may lessen the occurrence of infections and subsequently, reduce antibiotic use and medical consultations, said researchers from the University of Limerick, Ireland.

“[The new PEP device, SoloPEP] provides the same therapeutic effect as existing devices but eliminates the risk of infection because it is not used repeatedly over a long period of time and does not require cleaning,” said Professor Colum Dunne, Foundation Chair and Director of Research at the University of Limerick’s Graduate Entry Medical School, and co-principal investigator of the device.

Patients requiring PEP devices are taught how to use and clean the devices, and if proper cleaning instructions are not followed, the devices can become contaminated with bacteria, said Dunne.

“Noncompliance with cleaning happens as patients do not see it as necessary, they forget, or they simply do not have the time. The net effect is that patients who have presented with infections can be treated successfully with antibiotics, only to have the same infection recur as they breathe in the same problematic bacteria from their own poorly cleaned devices,” he said, noting that the new device will eliminate this risk.

According to Dunne, SoloPEP is an innovation involving a novel engineering mechanism that as per currently available PEP devices, “involves the patient exhaling against a fixed-orifice resistor or a threshold resistor, generating preset pressures”, an action which helps dislodge trapped mucus secretions and moves them towards larger airways to enable expulsion. [Hippokratia 2008;12:211-220] However, the SoloPEP device is smaller and due to its disposability, does not require cleaning, thus improving convenience, said Dunne.

Behind the development of the product is a multidisciplinary team including microbiologists, medical device engineers, and respiratory physicians who treat both adult and paediatric respiratory illness. Creation of this device was a multistep process which involved auditing bacterial outbreaks and detecting previously undetected bacteria in the nasal sinuses, said Dunne. The researchers also observed patients’ practices and discussed with them the challenges faced in using PEP devices.  

“This is a prime example of where patients and their carers provided the stimulus for innovation,” said Dunne. Products such as ours will help reduce antimicrobial use, reduce hospital stays, reduce numbers presenting at GPs and emergency rooms, and improve at-risk patients’ quality of life overall,” said Dunne.

The University of Limerick has recently received funding to develop the device which is expected to be on the market within 2 years and will be suitable for both adults and children.

From L-R: Prof Deirdre McGrath (respiratory consultant), Prof Colum Dunne (director of research), and Dr Leonard O' Sullivan (senior lecturer, design ergonomics)

From L-R: Prof Deirdre McGrath (respiratory consultant), Prof Colum Dunne (director of research), and Dr Leonard O' Sullivan (senior lecturer, design ergonomics)

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacy - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.