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Uncontrolled hypertension likely to have retinal vessel equivalents outside reference range

20 Jul 2017

Untreated or insufficiently treated hypertension is associated with retinal vessel equivalents outside the reference range, according to a recent study, which provides sex- and age-specific normative data for retinal vasculature.

Researchers assessed the fundus photographs from 4,309 participants of the Gutenberg Health Study using the retinal vessel analyser software (IMEDOS) to generate normative data for retinal vessel parameters and to evaluate the clinical relevance in systemic hypertension.

Sex- and age-specific nomograms in a disease-free subpopulation of 890 participants were generated to determine the central retinal arteriolar equivalent (CRAE), the central retinal venular equivalent and the arteriovenous ratio (AVR).

CRAE, AVR and central retinal venular equivalent values were greater in women than in men, and the decrease in measures with increasing age was less steep in women than in men.

Systemic hypertension correlated with lower values of AVR (men: odds ratio [OR], 2.41; 95 percent CI, 1.669 to 3.490; p<0.001; women: OR, 3.01; 2.126 to 4.268; p<0.001) and CRAE (men: OR, 2.60; 1.563 to 4.326; p<0.001; women: OR, 3.00; 2.004 to 4.487; p<0.001).

Participants with uncontrolled hypertension had lower median CRAE (172.28; range, 83.05 to 251.04) and AVR (0.81; 0.56 to 1.04) compared with those with screening-detected hypertension (CRAE, 175.72; 101.23 to 222.09; p<0.001; AVR, 0.82; 0.64 to 1.05; p=0.001) and those with controlled hypertension (CRAE, 179.10; 108.19 to 221.92; p<0.001; AVR, 0.84; 0.60 to 1.08; p<0.001).

“In-vivo measurement of retinal vascular calibers may be used as a tool to study the pathophysiology and clinical status of the microvasculature of the retina,” researchers said.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.