Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

U-prostasin concentration may help diagnose primary aldosteronism

24 Jan 2017

An elevated concentration of urinary prostasin (u-prostasin) in humans serves as a specific marker for primary aldosteronism, which involves the classical model of epithelial Na channel activation, according to a recent study.

However, there is no statistically significant difference in prostasin concentrations among patients with different primary aldosteronism subtypes.

Researchers recruited 62 primary aldosteronism and 56 essential hypertension patients to investigate if u-prostasin concentrations were higher in patients with primary aldosteronism than in patients with essential hypertension, and whether u-prostasin measurements could be a useful marker for detecting primary aldosteronism in hypertensive patients.

ELISA was used to measure u-prostasin levels, and routine laboratory methods were applied to assess biochemical and hormonal parameters.

Levels of u-prostasin were higher in primary aldosteronism patients than in essential hypertension patients. Prostasin levels were positively associated with the aldosterone-to-renin ratio and inversely associated with plasma K and urinary Na levels.

In the highest concentration quartile, an association was observed between u-prostasin levels and a several-fold higher probability of primary aldosteronism diagnosis in hypertensive patients. Based on a receiver operating characteristic curve analysis, prostasin was a specific but poorly sensitive diagnostic marker for primary aldosteronism.

The clinical usefulness of the prostasin assay could be further explained with more studies involving a larger series of patients, according to researchers.

“Prostasin is a glycosylphosphatidylinositol-anchored serine protease that is released in urine and is involved in epithelial Na channel activation,” researchers said. “A direct association between u-prostasin concentration and activation of the aldosterone-driven pathway has been suggested [in previous studies].”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.