Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

TyG-BMI predicts nonalcoholic fatty liver disease in nonobese individuals

08 Aug 2017

Triglyceride and glucose index in combination with body mass index (TyG-BMI) is an effective marker in detecting nonalcoholic fatty liver disease (NAFLD) in nonobese individuals, a new observational study has found.

The study included 6,809 nonobese Chinese adults (mean age 48.4±15.1 years; mean BMI, 22.0±2.0 kg/m2) with complete health examination data. Exclusion criteria were autoimmune hepatic diseases, chronic hepatic diseases, hepatic virus infections and diabetes or dyslipidaemia medications.

NAFLD diagnoses were delivered according to the Asia-Pacific Working Party guidelines. All participants underwent anthropometric measurements and routine biochemical laboratory tests.

NAFLD prevalence was 2.2 percent in the first TyG-BMI quartile and increased to 9.0 percent in the second. The prevalence further increased to 27.8 and 56.7 percent in the third and fourth quartiles of TyG-BMI, respectively.

Compared with participants in the first TyG-BMI quartile, those in the second (odds ratio [OR], 2.44; 95 percent CI, 1.6 to 3.6), third (OR, 6.4; 4.2 to 9.7) and fourth (OR, 15.3; 9.8 to 23.9) had higher risks of NAFLD after adjusting for blood pressure, serum biomarkers and BMI.

In the fully adjusted model, every 1-standard deviation increase in TyG-BMI also increased the risk of NAFLD (OR, 3.4; 3.0 to 3.9).

The diagnostic value of TyG-BMI (area under the receiver operating curve [AUROC], 0.835; 0.824 to 0.845; p<0.0001) was greater than that of BMI (AUROC, 0.783; 0.771 to 0.794; p<0.0001), TyG (AUROC 0.764; 0.751 to 0.777; p<0.0001), triglycerides (AUROC, 0.753; 0.739 to 0.766; p<0.0001) and fasting plasma glucose (AUROC, 0.625; 0.609 to 0.641; p<0.0001).

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.